ID   FEOB_LEPIN              Reviewed;         701 AA.
AC   Q8F332;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE   AltName: Full=Ferrous iron transport protein B;
GN   Name=feoB; OrderedLocusNames=LA_2579;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000250|UniProtKB:Q8GNS3}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P33650}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR   EMBL; AE010300; AAN49778.1; -; Genomic_DNA.
DR   RefSeq; NP_712760.1; NC_004342.2.
DR   RefSeq; WP_000510008.1; NC_004342.2.
DR   AlphaFoldDB; Q8F332; -.
DR   SMR; Q8F332; -.
DR   STRING; 189518.LA_2579; -.
DR   EnsemblBacteria; AAN49778; AAN49778; LA_2579.
DR   KEGG; lil:LA_2579; -.
DR   PATRIC; fig|189518.3.peg.2563; -.
DR   HOGENOM; CLU_013350_3_2_12; -.
DR   InParanoid; Q8F332; -.
DR   OMA; PLGYDWK; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; GTP-binding; Ion transport; Iron;
KW   Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..701
FT                   /note="Fe(2+) transporter FeoB"
FT                   /id="PRO_0000210838"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        523..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        645..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        672..692
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          9..172
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         16..23
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         41..46
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         62..65
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ   SEQUENCE   701 AA;  78128 MW;  CF65FA4D8078A91D CRC64;
     MGHSDSSKTF RILMAGNPNC GKSTLFNQLT GLRQKTGNYH GVTVEKAEGI FHHLDHSVKI
     LDLPGAFSLG GSSEDKQITS RVLIGHEAGD RILFVMDASL AERSLQFLLQ ILELNVPVLV
     AVTMKDVLEK KRVQLRLDLL SNEFGILFQY VNPKNGEGIK ELKDRIVSPK AFCLPIRSFP
     WDSERENFLN DLLNSLSTEH SNSLKFVLTN SLKELSGEIL QKGLPGLSLF SETPSKLIRE
     KFERFGKRFT YLEELTQKSI YIKKILSNAI VGDPIPNERV LSKADKILLH PFWGLVSFLG
     IMALVFQALF TWSEMPMDWI ESCVRNVGTF VGDFLEEGPL RSLIQEGIIG GVGAVLVFIP
     QISLLFLFIG ILEETGYIAR ASFVMDRFMG KFGLSGKSFI PLLSSAACAV PAIMGTRTIE
     NKSDRLTTIL VSPLITCSAR YPVYVLVIGA IFPSKNILGI FNVQALTMFG LFLLGMIASM
     FAALVFKKTF FKSDSSYFLI ELPAYNTPSI KSLALTVFKK LKAFLSTAGQ IILFISILLW
     FLANYPRIDS SLYPNLTDAE LKKIQIRESY AGHSGKFMEP VLKPIGFDWK MGIGIITSFA
     AREIMVSTLS IIYGVGGEES TDDLKEALLK DTDENGKPVW GLSNSVSLLL FFAFACQCMS
     TLAVVKKETN SIFWPLFLFT YMTILAYSTS FIVFQVWQLF S