ID   FEOB_SALPA              Reviewed;         772 AA.
AC   Q5PLZ1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE   AltName: Full=Ferrous iron transport protein B;
GN   Name=feoB; OrderedLocusNames=SPA3371;
OS   Salmonella paratyphi A (strain ATCC 9150 / SARB42).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=295319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9150 / SARB42;
RX   PubMed=15531882; DOI=10.1038/ng1470;
RA   McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S.,
RA   Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R.,
RA   Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.,
RA   Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W.,
RA   Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M.,
RA   Warren W., Florea L., Spieth J., Wilson R.K.;
RT   "Comparison of genome degradation in Paratyphi A and Typhi, human-
RT   restricted serovars of Salmonella enterica that cause typhoid.";
RL   Nat. Genet. 36:1268-1274(2004).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000250|UniProtKB:P33650}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P33650}.
CC   -!- INDUCTION: Iron uptake is repressed by the global regulator Fur.
CC       {ECO:0000250|UniProtKB:P33650}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR   EMBL; CP000026; AAV79184.1; -; Genomic_DNA.
DR   RefSeq; WP_000736984.1; NC_006511.1.
DR   AlphaFoldDB; Q5PLZ1; -.
DR   SMR; Q5PLZ1; -.
DR   EnsemblBacteria; AAV79184; AAV79184; SPA3371.
DR   KEGG; spt:SPA3371; -.
DR   HOGENOM; CLU_013350_3_0_6; -.
DR   OMA; PLGYDWK; -.
DR   Proteomes; UP000008185; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; GTP-binding; Ion transport; Iron;
KW   Iron transport; Membrane; Nucleotide-binding; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..772
FT                   /note="Fe(2+) transporter FeoB"
FT                   /id="PRO_0000210825"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        518..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        664..684
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        691..711
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        722..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          3..169
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         35..39
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         56..59
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         120..123
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         149..151
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ   SEQUENCE   772 AA;  84159 MW;  347BBA300D21FE4E CRC64;
     MKKLTIGLIG NPNSGKTTLF NQLTGARQRV GNWAGVTVER KEGQFATTDH QVTLVDLPGT
     YSLTTISSQT SLDEQIACHY ILSGDADLLI NVVDASNLER NLYLTLQLLE LGIPCIVALN
     MLDIAEKQQV RIDVDALSTR LGCPVVPLVS TRGRGIEALK LAIDRHNAND NVELVHYAQP
     LLREAGFLAD AMAQEMPLQQ RRWLGLQMLE GDIYSRAYAG EAAQNLDTSL ARLKDEMDDP
     ALHIADARYQ CIAAICDVVS NTLTAEPSRF TRAVDKIILN RFLGLPIFLF VMYLMFLLAI
     NIGGALQPLF DAGSVAIFIH GIQWIGYTLH FPDWLTIFLA QGLGGGINTV LPLVPQIGMM
     YLFLSFLEDS GYMARAAFVM DRLMQALGLP GKSFVPLIVG FGCNVPSVMG ARTLDAPRER
     LMTIMMAPFM SCGARLAIFA VFAAAFFGQN GALAVFSLYV LGIVMAVLTG LMLKHTIMRG
     EASPFVMELP VYHVPHIKSL IIQTWQRLKG FVLRAGKVII IVSIFLSAFN SFSLSGKIVD
     NINDSALASV SRVITPVFKP IGVHEDNWQA TVGLFTGAMA KEVVVGTLNT LYTAENIQDE
     AFNPADFHLG DELLGAVDDT WQSLKDTFSL SVLANPIEAS KGDGEMATGA MGVMDQKFGS
     AAAAYSYLIF VLLYVPCISV MGAIARESSR GWMSFSILWG LNIAYSLATL FYQVTSFSQH
     PTYSLICILA VIVFNVVVLS LLRRARSRVD IELLATRKSV TSCCSGTAGN CH