FEOB_SALTY
ID FEOB_SALTY Reviewed; 772 AA.
AC P74884;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 13-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein B;
GN Name=feoB; OrderedLocusNames=STM3506;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-330.
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=8890205; DOI=10.1128/iai.64.11.4549-4556.1996;
RA Tsolis R.M., Baumler A.J., Heffron F., Stojiljkovic I.;
RT "Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella
RT typhimurium in the mouse.";
RL Infect. Immun. 64:4549-4556(1996).
RN [3]
RP FUNCTION.
RC STRAIN=W;
RX PubMed=12379679; DOI=10.1128/iai.70.11.6032-6042.2002;
RA Boyer E., Bergevin I., Malo D., Gros P., Cellier M.F.M.;
RT "Acquisition of Mn(II) in addition to Fe(II) is required for full virulence
RT of Salmonella enterica serovar Typhimurium.";
RL Infect. Immun. 70:6032-6042(2002).
CC -!- FUNCTION: Probable transporter for a GTP-driven Fe(2+) uptake system.
CC {ECO:0000305|PubMed:12379679}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- INDUCTION: Iron uptake is repressed by the global regulator Fur.
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- MISCELLANEOUS: Acquisition of Mn(2+) in addition to Fe(2+) is required
CC for intercellular survival, replication in macrophages in vitro and for
CC full virulence in vivo. {ECO:0000269|PubMed:12379679}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR EMBL; AE006468; AAL22368.1; -; Genomic_DNA.
DR EMBL; U70434; AAB09706.1; -; Genomic_DNA.
DR RefSeq; NP_462409.1; NC_003197.2.
DR RefSeq; WP_000736973.1; NC_003197.2.
DR AlphaFoldDB; P74884; -.
DR SMR; P74884; -.
DR STRING; 99287.STM3506; -.
DR PaxDb; P74884; -.
DR EnsemblBacteria; AAL22368; AAL22368; STM3506.
DR GeneID; 1255029; -.
DR KEGG; stm:STM3506; -.
DR PATRIC; fig|99287.12.peg.3705; -.
DR HOGENOM; CLU_013350_3_0_6; -.
DR OMA; PLGYDWK; -.
DR PhylomeDB; P74884; -.
DR BioCyc; SENT99287:STM3506-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR041069; FeoB_Cyto.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF17910; FeoB_Cyto; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; GTP-binding; Ion transport; Iron;
KW Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..772
FT /note="Fe(2+) transporter FeoB"
FT /id="PRO_0000210827"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 664..684
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 722..742
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 3..169
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 35..39
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 56..59
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 120..123
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 149..151
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT CONFLICT 33..36
FT /note="WAGV -> NSAF (in Ref. 2; AAB09706)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="N -> Y (in Ref. 2; AAB09706)"
FT /evidence="ECO:0000305"
FT CONFLICT 302
FT /note="I -> V (in Ref. 2; AAB09706)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="D -> N (in Ref. 2; AAB09706)"
FT /evidence="ECO:0000305"
FT CONFLICT 327..330
FT /note="YTLH -> KPNS (in Ref. 2; AAB09706)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 772 AA; 84200 MW; 94BAEA80CAA485C7 CRC64;
MKKLTIGLIG NPNSGKTTLF NQLTGARQRV GNWAGVTVER KEGQFATTDH QVTLVDLPGT
YSLTTISSQT SLDEQIACHY ILSGDADLLI NVVDASNLER NLYLTLQLLE LGIPCIVALN
MLDIAEKQQV RIDVDALSTR LGCPVVPLVS TRGRGIEALK LAIDRHNAND NVELVHYAQP
LLREADFLAD AMAQEMPLQQ RRWLGLQMLE GDIYSRAYAG EAAQNLDTSL ARLKDEMDDP
ALHIADARYQ CIAAICDVVS NTLTAEPSRF TRAVDKIILN RFLGLPIFLF VMYLMFLLAI
NIGGALQPLF DAGSVAIFIH GIQWIGYTLH FPDWLTIFLA QGLGGGINTV LPLVPQIGMM
YLFLSFLEDS GYMARAAFVM DRLMQALGLP GKSFVPLIVG FGCNVPSVMG ARTLDAPRER
LMTIMMAPFM SCGARLAIFA VFAAAFFGQN GALAVFSLYV LGIVMAVLTG LMLKHTIMRG
EASPFVMELP VYHVPHIKSL IIQTWQRLKG FVLRAGKVII IVSIFLSAFN SFSLSGKIVD
NINDSALASV SRVITPVFKP IGVHEDNWQA TVGLFTGAMA KEVVVGTLNT LYTAENIQDE
AFNPADFHLG DELLGAVDDT WQSLKDTFSL SVLANPIEAS KGDGEMATGA MGVMDQKFGS
AAAAYSYLIF VLLYVPCISV MGAIARESSR GWMGFSILWG LNIAYSLATL FYQVTSFSQH
PTYSLICILA VIVFNVVVLS LLRRARSRVD IELLATRKNV SSCCSGTAGN CH
