FEOB_STAAM
ID FEOB_STAAM Reviewed; 664 AA.
AC Q99R86;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein B;
GN Name=feoB; OrderedLocusNames=SAV2550;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR EMBL; BA000017; BAB58712.1; -; Genomic_DNA.
DR RefSeq; WP_000432915.1; NC_002758.2.
DR AlphaFoldDB; Q99R86; -.
DR SMR; Q99R86; -.
DR PaxDb; Q99R86; -.
DR EnsemblBacteria; BAB58712; BAB58712; SAV2550.
DR KEGG; sav:SAV2550; -.
DR HOGENOM; CLU_013350_3_0_9; -.
DR OMA; PLGYDWK; -.
DR PhylomeDB; Q99R86; -.
DR BioCyc; SAUR158878:SAV_RS13910-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR041069; FeoB_Cyto.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF17910; FeoB_Cyto; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell membrane; GTP-binding; Ion transport; Iron; Iron transport; Membrane;
KW Nucleotide-binding; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..664
FT /note="Fe(2+) transporter FeoB"
FT /id="PRO_0000210842"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 608..628
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 637..657
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..161
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 8..15
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 33..37
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 52..55
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 112..115
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 141..143
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ SEQUENCE 664 AA; 74353 MW; 1F8D4CDD57BFD88C CRC64;
MENYCILGNP NVGKTSLFNA LTGSYEYIGN WSGVTVEKKV GKLKENVGQL IDLPGTYDLS
PISKDETVVT DYLLNDSFSG IINIVDASQL KRNVQLTVQL LELNQPIYIG LNMIDVATKR
GIKIDYHKLM KKLKTPIFPV VARTGKGTKY LLGEIKHLGE GYQPHFKINY GEKIEETIKN
MCQIIMTETS HDKYQARFIA IQFLLNNMQI ANELNSEVVN KLSSLRDQVA EQVGAVSVRR
EMERIRNHYI ETLLQDVVTY PDEDKQYFSS RIDKILTHKY IGMPIFLAIM WLIFQTTFTW
IGTPLSDQLD AFIGGTFTDS VKTIMNYLGV IPFLQDLITD GIIAGVGSVL VFVPQIVVLF
FFISLLEDSG YMARIAVLMD RIMESFGLSG KSFIPMIIGF GCNVPSIMAA RSIENEKERL
TTILIAPFMS CSARLPVYAL FVGIFFKENQ SLVVLSLYVL GIIMAFLVST VLTKTILKND
NAIFIVELPT YRVPSIKTLW RSTWEKAKGF VRKAGTFIFG GSVVIWLLSY VGPHGINVNI
NQSFLHMVGS FFGMLVQPLG FGTWQAGATL VPGFLAKEVI VSSMAIIYSS GDAGLVNVIQ
NQFTPLSAYA FMIFILLYIP CVSTVAAIRK ETYSWKWTAL AVAYPLVTAY VLTFIFYQVG
HLFV
