ID   FEOB_STAAW              Reviewed;         664 AA.
AC   Q8NUR5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE   AltName: Full=Ferrous iron transport protein B;
GN   Name=feoB; OrderedLocusNames=MW2471;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000250|UniProtKB:P33650}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR   EMBL; BA000033; BAB96336.1; -; Genomic_DNA.
DR   RefSeq; WP_000432897.1; NC_003923.1.
DR   AlphaFoldDB; Q8NUR5; -.
DR   SMR; Q8NUR5; -.
DR   EnsemblBacteria; BAB96336; BAB96336; BAB96336.
DR   KEGG; sam:MW2471; -.
DR   HOGENOM; CLU_013350_3_0_9; -.
DR   OMA; PLGYDWK; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; GTP-binding; Ion transport; Iron; Iron transport; Membrane;
KW   Nucleotide-binding; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..664
FT                   /note="Fe(2+) transporter FeoB"
FT                   /id="PRO_0000210846"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        544..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        567..587
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        608..628
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        637..657
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..161
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         8..15
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         33..37
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         52..55
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         112..115
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         141..143
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ   SEQUENCE   664 AA;  74517 MW;  B3120CE0061DC273 CRC64;
     MENYCILGNP NVGKTSLFNA LTGSYEYIGN WSGVTVEKKV GKLKENVGQL IDLPGTYDLS
     PISKDETVVT DYLLNDSFSG IINIVDASQL KRNMQLTVQL LELNQPIYIG LNMIDVATKR
     GIKIDYHKLM KKLKTPIFPV VARTGKGTKH LLGEIKHLGE GYQPHFKINY GEKIEETIKN
     MCQIIMTETS HDKYQARFIA IQFLLNNMQI ANELNSEVVN KLSSLRDQVD KQVEAVSVRR
     EMERIRNHYI ETLLQDVVTY PDEDKQYFSS RIDKILTHKY IGMPIFLAIM WLIFQTTFTW
     IGTPLSDQLD AFIGGTFTDS VKTIMNYLGV IPFLQDLITD GIIAGVGSVL VFVPQIVVLF
     FFISLLEDSG YMARIAVLMD RIMESFGLSG KSFIPMIIGF GCNVPSIMAA RSIENEKERL
     TTILIAPFMS CSARLPVYAL FVGIFFKENQ SLVVLSLYVL GIIMAFLVST VLTKTILKND
     NAIFIVELPT YRVPSIKTLW RSTWEKAKGF VRKAGTFIFG GSVVIWLLSY VGPHGINVNI
     NQSFLHMVGS FFGMLVQPLG FGTWQAGATL VPGFLAKEVI VSSMAIIYSS GDAGLVNVIQ
     NQFTPLSAYA FMIFILLYIP CVSTVAAIRK ETYSWKWTAL AVVYPLVTAY VLTFIFYQIG
     HLFV