FEOC_ECOLI
ID FEOC_ECOLI Reviewed; 78 AA.
AC P64638; P46845; Q2M775;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Probable [Fe-S]-dependent transcriptional repressor FeoC {ECO:0000255|HAMAP-Rule:MF_01586, ECO:0000303|PubMed:16718600};
DE AltName: Full=Fe(2+) iron transport protein C {ECO:0000305};
GN Name=feoC {ECO:0000255|HAMAP-Rule:MF_01586}; Synonyms=yhgG;
GN OrderedLocusNames=b3410, JW3373;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP INDUCTION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15647275; DOI=10.1074/jbc.m410393200;
RA Flatley J., Barrett J., Pullan S.T., Hughes M.N., Green J., Poole R.K.;
RT "Transcriptional responses of Escherichia coli to S-nitrosoglutathione
RT under defined chemostat conditions reveal major changes in methionine
RT biosynthesis.";
RL J. Biol. Chem. 280:10065-10072(2005).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=16718600; DOI=10.1007/s10534-006-0003-2;
RA Cartron M.L., Maddocks S., Gillingham P., Craven C.J., Andrews S.C.;
RT "Feo -- transport of ferrous iron into bacteria.";
RL BioMetals 19:143-157(2006).
RN [5]
RP STRUCTURE BY NMR.
RG Northeast structural genomics consortium (NESG);
RT "Solution structure of E.coli protein yhgG: the northeast structural
RT genomics consortium target ET95.";
RL Submitted (JAN-2005) to the PDB data bank.
CC -!- FUNCTION: May function as a transcriptional regulator that controls
CC feoABC expression. {ECO:0000255|HAMAP-Rule:MF_01586,
CC ECO:0000269|PubMed:16718600}.
CC -!- INDUCTION: Up-regulated by S-nitrosoglutathione under anaerobic
CC conditions. Repressed by the global regulator Fur.
CC {ECO:0000269|PubMed:15647275, ECO:0000269|PubMed:16718600}.
CC -!- SIMILARITY: Belongs to the FeoC family. {ECO:0000255|HAMAP-
CC Rule:MF_01586, ECO:0000305}.
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DR EMBL; U18997; AAA58208.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76435.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77881.1; -; Genomic_DNA.
DR PIR; E65136; E65136.
DR RefSeq; NP_417869.1; NC_000913.3.
DR RefSeq; WP_000157586.1; NZ_STEB01000004.1.
DR PDB; 1XN7; NMR; -; A=1-78.
DR PDBsum; 1XN7; -.
DR AlphaFoldDB; P64638; -.
DR SMR; P64638; -.
DR BioGRID; 4263492; 22.
DR BioGRID; 852227; 3.
DR IntAct; P64638; 3.
DR STRING; 511145.b3410; -.
DR PaxDb; P64638; -.
DR PRIDE; P64638; -.
DR EnsemblBacteria; AAC76435; AAC76435; b3410.
DR EnsemblBacteria; BAE77881; BAE77881; BAE77881.
DR GeneID; 66672708; -.
DR GeneID; 947918; -.
DR KEGG; ecj:JW3373; -.
DR KEGG; eco:b3410; -.
DR PATRIC; fig|1411691.4.peg.3319; -.
DR EchoBASE; EB2769; -.
DR eggNOG; ENOG50330S2; Bacteria.
DR HOGENOM; CLU_189182_0_0_6; -.
DR OMA; CLSGGCK; -.
DR PhylomeDB; P64638; -.
DR BioCyc; EcoCyc:EG12933-MON; -.
DR EvolutionaryTrace; P64638; -.
DR PRO; PR:P64638; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:EcoCyc.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0033212; P:iron import into cell; IGC:EcoCyc.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01586; FeoC; 1.
DR InterPro; IPR023732; FeoC.
DR InterPro; IPR015102; Tscrpt_reg_HTH_FeoC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09012; FeoC; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Iron; Iron-sulfur; Metal-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..78
FT /note="Probable [Fe-S]-dependent transcriptional repressor
FT FeoC"
FT /id="PRO_0000169546"
FT BINDING 56
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01586,
FT ECO:0000305|PubMed:16718600"
FT BINDING 61
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01586,
FT ECO:0000305|PubMed:16718600"
FT BINDING 64
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01586,
FT ECO:0000305|PubMed:16718600"
FT BINDING 70
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01586,
FT ECO:0000305|PubMed:16718600"
FT HELIX 4..13
FT /evidence="ECO:0007829|PDB:1XN7"
FT HELIX 19..25
FT /evidence="ECO:0007829|PDB:1XN7"
FT HELIX 30..43
FT /evidence="ECO:0007829|PDB:1XN7"
FT STRAND 45..49
FT /evidence="ECO:0007829|PDB:1XN7"
FT STRAND 74..77
FT /evidence="ECO:0007829|PDB:1XN7"
SQ SEQUENCE 78 AA; 8660 MW; 88976DE22CA9024B CRC64;
MASLIQVRDL LALRGRMEAA QISQTLNTPQ PMINAMLQQL ESMGKAVRIQ EEPDGCLSGS
CKSCPEGKAC LREWWALR
