ID   AJAP1_XENTR             Reviewed;         390 AA.
AC   Q0IIY7;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Adherens junction-associated protein 1;
DE   Flags: Precursor;
GN   Name=ajap1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in cell adhesion and cell migration.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000250|UniProtKB:Q9UKB5}; Single-pass type I membrane protein
CC       {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9UKB5};
CC       Single-pass type I membrane protein {ECO:0000255}. Cell junction,
CC       adherens junction {ECO:0000250|UniProtKB:Q9UKB5}. Note=Mainly
CC       basolateral. {ECO:0000250|UniProtKB:Q9UKB5}.
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DR   EMBL; BC121464; AAI21465.1; -; mRNA.
DR   RefSeq; NP_001072363.1; NM_001078895.1.
DR   AlphaFoldDB; Q0IIY7; -.
DR   PaxDb; Q0IIY7; -.
DR   PRIDE; Q0IIY7; -.
DR   DNASU; 779816; -.
DR   GeneID; 779816; -.
DR   KEGG; xtr:779816; -.
DR   CTD; 55966; -.
DR   Xenbase; XB-GENE-990276; ajap1.
DR   eggNOG; ENOG502QVMU; Eukaryota.
DR   InParanoid; Q0IIY7; -.
DR   OrthoDB; 770398at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044291; C:cell-cell contact zone; IBA:GO_Central.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0044214; C:spanning component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR039239; AJAP1.
DR   InterPro; IPR029198; AJAP1_PANP_C.
DR   PANTHER; PTHR32422; PTHR32422; 1.
DR   Pfam; PF15298; AJAP1_PANP_C; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Cell membrane; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..390
FT                   /note="Adherens junction-associated protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000284804"
FT   TOPO_DOM        38..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..390
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          218..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          283..390
FT                   /note="Targeting signals"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        218..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   390 AA;  43931 MW;  D94D4808FFBA842C CRC64;
     MWITQLLGIR SGPPLGSHAW ILIAIFQLAM DFIICESESP GKAYKHLQRP SLVRRVHKVA
     LWSPTELLKL RNQKQFWNPI NNEHPVLPIE RKHYKTYHEN LFFSRNVPLK YSTMKNSHYS
     SQQIKHTVKT TNLNRSKRQL QSRSWDNLKR FLDSGSQPTT VSEFILWGPT GDDDVESSTF
     PGIYETTRTS TVHARTTLLE TTTTTTASTT TNVKVTTLQN PGIHNGKKSP GRISTTDPNP
     GNGKTARPPR IPNDTSGLAV HQIITITVSL IMVIAALITT LVLKNCCAQS GNARRNSHQR
     KINQQEESCQ NLTDFTPASV PSNMDIFTAY NETLHCSHEC IRTPVPVYTD EALHQTGAFK
     TTFNGNRPTS SDRHLIPVAF VSEKWFEISC