FEPE_ECOLI
ID FEPE_ECOLI Reviewed; 377 AA.
AC P26266; Q2MBL4;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Ferric enterobactin transport protein FepE;
GN Name=fepE; OrderedLocusNames=b0587, JW0579;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RA Shea Cleavinger C.M., Ozenberger B., McIntosh M.;
RL Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89.
RC STRAIN=K12;
RX PubMed=1826089; DOI=10.1021/bi00225a027;
RA Rusnak F., Sakaitani M., Drueckhammer D., Reichert J., Walsh C.T.;
RT "Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of
RT the entF gene, expression and purification of EntF, and analysis of
RT covalent phosphopantetheine.";
RL Biochemistry 30:2916-2927(1991).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [7]
RP OPERON STRUCTURE, AND INDUCTION.
RC STRAIN=K12 / BW25113;
RX PubMed=19429622; DOI=10.1128/jb.00108-09;
RA Shimada T., Yamamoto K., Ishihama A.;
RT "Involvement of the leucine response transcription factor LeuO in
RT regulation of the genes for sulfa drug efflux.";
RL J. Bacteriol. 191:4562-4571(2009).
CC -!- FUNCTION: Part of the ferric enterobactin transport system.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- INDUCTION: Repressed by H-NS, induced by LeuO. A monocistronic operon.
CC {ECO:0000269|PubMed:19429622}.
CC -!- SIMILARITY: Belongs to the WzzB/Cld/Rol family. {ECO:0000305}.
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DR EMBL; X74129; CAA52226.1; -; Genomic_DNA.
DR EMBL; U82598; AAB40786.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73688.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76342.1; -; Genomic_DNA.
DR EMBL; M60177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S34703; S34703.
DR RefSeq; NP_415119.1; NC_000913.3.
DR RefSeq; WP_000096692.1; NZ_LN832404.1.
DR AlphaFoldDB; P26266; -.
DR SMR; P26266; -.
DR BioGRID; 4259898; 146.
DR BioGRID; 849566; 4.
DR DIP; DIP-9596N; -.
DR IntAct; P26266; 9.
DR STRING; 511145.b0587; -.
DR PaxDb; P26266; -.
DR PRIDE; P26266; -.
DR EnsemblBacteria; AAC73688; AAC73688; b0587.
DR EnsemblBacteria; BAE76342; BAE76342; BAE76342.
DR GeneID; 945180; -.
DR KEGG; ecj:JW0579; -.
DR KEGG; eco:b0587; -.
DR PATRIC; fig|1411691.4.peg.1682; -.
DR EchoBASE; EB0293; -.
DR eggNOG; COG3765; Bacteria.
DR HOGENOM; CLU_060925_3_0_6; -.
DR InParanoid; P26266; -.
DR OMA; RQYYVEQ; -.
DR PhylomeDB; P26266; -.
DR BioCyc; EcoCyc:EG10297-MON; -.
DR PRO; PR:P26266; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015620; F:ferric-enterobactin transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0015685; P:ferric-enterobactin import into cell; IMP:EcoCyc.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR Pfam; PF02706; Wzz; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..377
FT /note="Ferric enterobactin transport protein FepE"
FT /id="PRO_0000087225"
FT TOPO_DOM 1..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..338
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..377
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 377 AA; 42100 MW; 1C81D51BBFC3A499 CRC64;
MSSLNIKQGS DAHFPDYPLA SPSNNEIDLL NLISVLWRAK KTVMAVVFAF ACAGLLISFI
LPQKWTSAAV VTPPEPVQWQ ELEKSFTKLR VLDLDIKIDR TEAFNLFIKK FQSVSLLEEY
LRSSPYVMDQ LKEAKIDELD LHRAIVALSE KMKAVDDNAS KKKDEPSLYT SWTLSFTAPT
SEEAQTVLSG YIDYISTLVV KESLENVRNK LEIKTQFEKE KLAQDRIKTK NQLDANIQRL
NYSLDIANAA GIKKPVYSNG QAVKDDPDFS ISLGADGIER KLEIEKAVTD VAELNGELRN
RQYLVEQLTK AHVNDVNFTP FKYQLSPSLP VKKDGPGKAI IVILSALIGG MVACGGVLLR
YAMASRKQDA MMADHLV
