FER1_CAEEL
ID FER1_CAEEL Reviewed; 2034 AA.
AC Q17388;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Sperm vesicle fusion protein fer-1;
GN Name=fer-1; ORFNames=F43G9.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9175703; DOI=10.1242/jcs.110.9.1073;
RA Achanzar W.E., Ward S.;
RT "A nematode gene required for sperm vesicle fusion.";
RL J. Cell Sci. 110:1073-1081(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for the fusion of the membranous organelles (MOs)
CC with the plasma membrane, a process essential in spermiogenesis.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in the testis.
CC -!- SIMILARITY: Belongs to the ferlin family. {ECO:0000305}.
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DR EMBL; U57652; AAB02243.1; -; Genomic_DNA.
DR EMBL; Z79755; CAB02109.1; -; Genomic_DNA.
DR PIR; T22147; T22147.
DR RefSeq; NP_492337.1; NM_059936.3.
DR AlphaFoldDB; Q17388; -.
DR BioGRID; 38092; 4.
DR STRING; 6239.F43G9.6a; -.
DR PaxDb; Q17388; -.
DR EnsemblMetazoa; F43G9.6a.1; F43G9.6a.1; WBGene00001414.
DR GeneID; 172659; -.
DR KEGG; cel:CELE_F43G9.6; -.
DR UCSC; F43G9.6b; c. elegans.
DR CTD; 172659; -.
DR WormBase; F43G9.6a; CE10364; WBGene00001414; fer-1.
DR eggNOG; KOG1326; Eukaryota.
DR GeneTree; ENSGT00940000167153; -.
DR InParanoid; Q17388; -.
DR OMA; KHCGRTQ; -.
DR OrthoDB; 20162at2759; -.
DR PhylomeDB; Q17388; -.
DR PRO; PR:Q17388; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001414; Expressed in germ cell and 5 other tissues.
DR ExpressionAtlas; Q17388; baseline and differential.
DR GO; GO:0031301; C:integral component of organelle membrane; IDA:WormBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:WormBase.
DR GO; GO:0032809; C:neuronal cell body membrane; IDA:WormBase.
DR GO; GO:0031260; C:pseudopodium membrane; IDA:WormBase.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; ISS:WormBase.
DR GO; GO:0097723; P:amoeboid sperm motility; IMP:WormBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0061025; P:membrane fusion; IMP:WormBase.
DR GO; GO:0007009; P:plasma membrane organization; IMP:WormBase.
DR GO; GO:0031268; P:pseudopodium organization; IMP:WormBase.
DR GO; GO:0007283; P:spermatogenesis; IMP:WormBase.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; -; 3.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; PTHR12546; 1.
DR Pfam; PF00168; C2; 4.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 4.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SUPFAM; SSF49562; SSF49562; 4.
DR PROSITE; PS50004; C2; 5.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Membrane; Reference proteome;
KW Repeat; Spermatogenesis; Transmembrane; Transmembrane helix.
FT CHAIN 1..2034
FT /note="Sperm vesicle fusion protein fer-1"
FT /id="PRO_0000057885"
FT TOPO_DOM 1..1998
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1999..2019
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2020..2034
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 229..367
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 954..1082
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 1120..1246
FT /note="C2 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 1363..1484
FT /note="C2 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 1684..1831
FT /note="C2 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1563..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1952..1972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2034 AA; 235241 MW; 402A42532618896B CRC64;
MTVKEKLLKV KQKFKRGDSS SDVDSGPERD RDEDDSDNES RNTSKTSKSS KKSKSGKSTG
TSEMTELSDD GGSDIELLPD DGKSFGKRKL QDTDKPCTWN VLVRIIEAKD VSTGSARVRT
IFDGNSKMTR TVTHAIPKWR QNILYTIKNQ PLEKLAAKVL TLRLVRPTAL GESSVGEFSC
YLSEVIHSPD RSVIAKWVAL GFPGMDDEEP DDIAYENCGF LKVTLSVYRI DESPPTLIDD
DGKEQIWSGA HLIDYTLKIR VFSVEQLIRQ MINERKIKKK QRFYVMVQCG AHKTETTMES
AFLDEDANIA SVKFEQEIYL PIQWPTVISE IIFSLFDKKG RGKTCIGKAT LPMKMIYEPG
ETGYLPTFGP AFLNVFDCER VTRFSIFSRK MRGSQQDGSR FVGRLFIAID CVEYMEKANA
QIMHLDHSPI MEAESICKNL EWYNCFCSMS GLNMINPQFA SDPVCIMMSI GSFGSTSNEF
RSCNSSTLPA EPNWDGCKYF TMPWGNLRPV AEVNAPWEVI EHRIEMSNVL MKMTNMLDTM
IWEVRRIGNK AIDHVSSVGM EALECLEQQI DSASKYLGRI NPVSSNALDR HILDYRKEKI
LKLREHFEKE AFSIDYSDGE VDAKLLRMLL KIRSMTLELA EDVQMTIPPV LIKMMSHGKL
IGFAKIPISE IFQSDDEAQS GEWCGRTRAI NIQWPTLVDQ RNRKREHVAV LHAKMWFGRT
DQLTKWKEHV QPADIRRFME MYEVQTKGLA LKWKDEADIY DGKWEKTNEV PLENGWNAVG
HWIVMNTRHM FVPKLGQHTV HDKAFEIQKR TEDGTWKHFK YTDCYADELK PKDLDKHAKG
WEVGSWAQDK FRNNGDEKGW VYSTNGVFFG SGVLTDREEK VHHNFRKRCI KRPRKHEGYN
KELEDFEHFR TTMGNENWEY SPSKKEGPYH DLEDRTDRIR RRRYVREVEN KDPDSEDPRF
RVYEYQMQTG KWQLRCYIMW GNDLLPVVKN SSRAFVRISF AQYSKQTLLV DNSQNPIWNE
TVMFKSVLIA GGTRDIMKYP PVVSVEVVGE CSNNEEANLG HFETKPNVIC GNTDVRGTPQ
WFPLKFSNGR TRGAVLACFE LYSEEDKDLI PLEPKCKHNY KERSEIPTEF RPQFDKFHVQ
FLCWGVRNLK KHKLLAVRRP FVGLTIGDQE FTLQPLKDVR RDPNFPEPMI VFGEVILPSA
LELSPPLIIN LFDARAFNRQ PLVGSCLVSD LHKYVSHIVP KVKSDHAERW EQLDLVITEE
FDQIIRMVRV PTLTTDPMVP LDWWSRYYAS MSQFHRSPGY PESGMEYVRI FRRPLEQMNG
YNNFSDFLDT FPFVKSMKGD FDDPEEKEKA GELKCRLLIS KLKKGKPPAA INTVVDFVGP
TRCLVRVYII EANGLISNAR KGRVDSYVKL HCGKQNVNLK KNYRSECCDP IFGERVDMTV
TIPLEKDLKI TVMGKRRILS DQEIGSTTID LENRLLTKWR ATGGLSGQFT VQGELQWRDQ
MTPMEILKSY CYKMMLSVPK IESRQTERGE EKGITIEKIT FWFSEVLHVF ENEEIAMLNS
QRQKAGKENF SDGSDQQNED VSDGSWDEED LEREKEKLKW EKHRSKGKPL KKVTTEKAET
ADGELRKKAK MRIMGSQLQT IALFILRQMN LVPEHVESRP LFSDKGGRTQ KGELRMFVDI
FPMEYGAIPA PFNIAPRKPI NYQLRIAVMD VRGAIPVKRS FAEPVSDLYV KAFINGMTKG
HKTDTHFRVL DGTGEFNWRF LLNFDYNPWE KKVVAYTKNR FFCKPVEELV DPILVIELWD
KNKFRKDRLL GDIELDLLDF IEGIGSPSDV GVYSTKKRQR GVKCPKCCTR RGCLCKCCIF
CFETKCLCGK RKVKKKPFPK PVLFVEPEGY DDTVNIFESR NLYGWWPMLT EEYPHEEPQN
AKKKNDDVGK DPKWIMGLVE MDMLLLTKQE ADQEPAGKKR SEPNHSPFLE KPDRKSWANS
WLVSRIKPCI KYFWHYYGLQ ILLWLIIIVI LILTIFVLLH TWPTILAEII KAIF
