FER3L_MOUSE
ID FER3L_MOUSE Reviewed; 168 AA.
AC Q923Z4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Fer3-like protein;
DE AltName: Full=Basic helix-loop-helix protein N-twist;
DE AltName: Full=Nephew of atonal 3;
DE AltName: Full=Neuronal twist;
GN Name=Ferd3l; Synonyms=Nato, Ntwist;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/Sv;
RX PubMed=11472856; DOI=10.1016/s0925-4773(01)00437-3;
RA Segev E., Halachmi N., Salzberg A., Ben-Arie N.;
RT "Nato3 is an evolutionarily conserved bHLH transcription factor expressed
RT in the CNS of Drosophila and mouse.";
RL Mech. Dev. 106:197-202(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TCF3, AND TISSUE
RP SPECIFICITY.
RC STRAIN=129/Sv;
RX PubMed=12217327; DOI=10.1006/dbio.2002.0753;
RA Verzi M.P., Anderson J.P., Dodou E., Kelly K.K., Greene S.B., North B.J.,
RA Cripps R.M., Black B.L.;
RT "N-twist, an evolutionarily conserved bHLH protein expressed in the
RT developing CNS, functions as a transcriptional inhibitor.";
RL Dev. Biol. 249:174-190(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription factor that binds to the E-box and functions as
CC inhibitor of transcription. DNA binding requires dimerization with an E
CC protein. Inhibits transcription activation by ASCL1/MASH1 by
CC sequestering E proteins. {ECO:0000269|PubMed:12217327}.
CC -!- SUBUNIT: Heterodimer with TCF3/E12. Interacts with the bHLH domain of
CC TCF3/E12. {ECO:0000269|PubMed:12217327}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in the developing central nervous system,
CC in particular in embryonic ventral neural tube, brain, and spinal cord.
CC Detected in embryonic intestine. Detected in embryonic and adult
CC thalamus, hypothalamus, midbrain, pons and medulla.
CC {ECO:0000269|PubMed:11472856, ECO:0000269|PubMed:12217327}.
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DR EMBL; AF369896; AAK72955.1; -; Genomic_DNA.
DR EMBL; AF517121; AAN04085.1; -; mRNA.
DR EMBL; BC111576; AAI11577.1; -; mRNA.
DR CCDS; CCDS25878.1; -.
DR RefSeq; NP_277057.1; NM_033522.2.
DR AlphaFoldDB; Q923Z4; -.
DR SMR; Q923Z4; -.
DR BioGRID; 227826; 1.
DR STRING; 10090.ENSMUSP00000058994; -.
DR iPTMnet; Q923Z4; -.
DR PhosphoSitePlus; Q923Z4; -.
DR PaxDb; Q923Z4; -.
DR PRIDE; Q923Z4; -.
DR Antibodypedia; 11904; 87 antibodies from 20 providers.
DR DNASU; 114712; -.
DR Ensembl; ENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518.
DR GeneID; 114712; -.
DR KEGG; mmu:114712; -.
DR UCSC; uc007niv.1; mouse.
DR CTD; 222894; -.
DR MGI; MGI:2150010; Ferd3l.
DR VEuPathDB; HostDB:ENSMUSG00000046518; -.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00940000161409; -.
DR HOGENOM; CLU_148882_0_0_1; -.
DR InParanoid; Q923Z4; -.
DR OMA; LDGCSRQ; -.
DR OrthoDB; 1513995at2759; -.
DR PhylomeDB; Q923Z4; -.
DR BioGRID-ORCS; 114712; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q923Z4; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q923Z4; protein.
DR Bgee; ENSMUSG00000046518; Expressed in ureteric bud trunk and 36 other tissues.
DR Genevisible; Q923Z4; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048468; P:cell development; IMP:MGI.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0033504; P:floor plate development; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:1904338; P:regulation of dopaminergic neuron differentiation; IMP:MGI.
DR GO; GO:0050767; P:regulation of neurogenesis; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..168
FT /note="Fer3-like protein"
FT /id="PRO_0000328683"
FT DOMAIN 103..155
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 65..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..80
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 168 AA; 19463 MW; 960BA60C19E7237B CRC64;
MAAYPESCLD ATVLNFVADL SLASPRHPLL CEFPPGVPFG DRTLGYREGR PGRLSQFDER
YQEVEGDEVE YEDPEEEEEE GEGRGRVASL LGRPKRKRVI TYAQRQAANI RERKRMFNLN
EAFDQLRRKV PTFAYEKRLS RIETLRLAIV YISFMTELLQ SKEEKEAS
