FER7_USTMA
ID FER7_USTMA Reviewed; 659 AA.
AC A1A654;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Siderophore transporter fer7 {ECO:0000303|PubMed:17138696};
DE AltName: Full=Fe-regulated protein 7 {ECO:0000303|PubMed:17138696};
GN Name=fer7 {ECO:0000303|PubMed:17138696}; ORFNames=UMAG_11339;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INDUCTION, AND FUNCTION.
RC STRAIN=521 / FGSC 9021;
RX PubMed=17138696; DOI=10.1105/tpc.106.043588;
RA Eichhorn H., Lessing F., Winterberg B., Schirawski J., Kamper J.,
RA Muller P., Kahmann R.;
RT "A ferroxidation/permeation iron uptake system is required for virulence in
RT Ustilago maydis.";
RL Plant Cell 18:3332-3345(2006).
RN [4]
RP FUNCTION.
RC STRAIN=521 / FGSC 9021;
RA Winterberg B., Uhlmann S., Linne U., Lessing F., Marahiel M.A.,
RA Eichhorn H., Kahmann R., Schirawski J.;
RT "Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago
RT maydis.";
RL Mol. Microbiol. 75:1260-1271(2010).
CC -!- FUNCTION: Siderophore transporter; part of the gene cluster that
CC mediates the biosynthesis of siderophore ferrichrome A which is
CC contributing to organismal virulence (PubMed:17138696, Ref.4).
CC {ECO:0000269|PubMed:17138696, ECO:0000269|Ref.4}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Expression regulated by iron through the urbs1 transcription
CC factor (PubMed:17138696). {ECO:0000269|PubMed:17138696}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM003141; KIS71537.1; -; Genomic_DNA.
DR EMBL; BK004083; DAA04935.1; -; Genomic_DNA.
DR RefSeq; XP_011387441.1; XM_011389139.1.
DR AlphaFoldDB; A1A654; -.
DR STRING; 5270.UM01430P0; -.
DR EnsemblFungi; KIS71537; KIS71537; UMAG_11339.
DR GeneID; 23567235; -.
DR KEGG; uma:UMAG_11339; -.
DR VEuPathDB; FungiDB:UMAG_11339; -.
DR eggNOG; KOG0254; Eukaryota.
DR eggNOG; KOG2495; Eukaryota.
DR OrthoDB; 641071at2759; -.
DR Proteomes; UP000000561; Chromosome 2.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Virulence.
FT CHAIN 1..659
FT /note="Siderophore transporter fer7"
FT /id="PRO_0000441963"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 415
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 475
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 659 AA; 72117 MW; 91DB36B7FE6605EE CRC64;
MSNQAQDQPE RRDSSSENSS PFKDDEVAAD QSVSAHGNTS LNKKDRVSAV RDADASSARE
GQQPGVTRIE ALYRIFPRNS PIVYTVYASL AAVTICFALD QSTTAAYQLY ATRTLGSHAK
LFGVIATVEA ILNAVSKPFI AKICDIFSRQ TAYFLVAVFY TIGFVVVASA QTPAAFAVGR
IITEVGQAGF DLVTDIVVAD LSPLEWRGVV TALTSSPFIV LPWVGNLIQA RLNTGRPEGW
RWGYGMFAIM APVCVAPIIL VLMYVDRKAQ KAGELSFASS RLETRRAQEQ GTVKVQRDSL
RDRFANLVQL CKEMDLVGLF LLALSFSLLL VPFSIYKDAD KQWRNPSIIA MFVCGGVILG
MFLAWEILLA SHPVMNKRVW YNRTFLLAVT IDIFYFMGGN ARSTYYGSFV LVGTNLSTAN
WGYVVNALAT CALSVFGLAA GFYLRIFHRY KFLQIGGLVI RIVAMGLYLY GRNGNLTTMV
VAWSQILNSL GGACSVVGTR VASQASVPHQ DLASIISQLA LWTRLGGAIG SAIAAGIWTG
TLPDYLAATN LTPAQQSRAY NSPTTIKTSY PWNTPLRNQI NQAFSKTMKP IFIVALVLAF
IPLFAGLLMP NYYLGKTQNA VDGTDNSGRV IESAEDNPNA EINRKNVKYA KGTRLSWLW
