ID   FER8_USTMA              Reviewed;         398 AA.
AC   A1A653;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Fe-regulated protein 8 {ECO:0000303|PubMed:17138696};
GN   Name=fer8 {ECO:0000303|PubMed:17138696}; ORFNames=UMAG_11338;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INDUCTION, AND FUNCTION.
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17138696; DOI=10.1105/tpc.106.043588;
RA   Eichhorn H., Lessing F., Winterberg B., Schirawski J., Kamper J.,
RA   Muller P., Kahmann R.;
RT   "A ferroxidation/permeation iron uptake system is required for virulence in
RT   Ustilago maydis.";
RL   Plant Cell 18:3332-3345(2006).
RN   [4]
RP   FUNCTION.
RC   STRAIN=521 / FGSC 9021;
RA   Winterberg B., Uhlmann S., Linne U., Lessing F., Marahiel M.A.,
RA   Eichhorn H., Kahmann R., Schirawski J.;
RT   "Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago
RT   maydis.";
RL   Mol. Microbiol. 75:1260-1271(2010).
CC   -!- FUNCTION: Protein of unknown function; part of the gene cluster that
CC       mediates the biosynthesis of siderophore ferrichrome A which is
CC       contributing to organismal virulence (PubMed:17138696, Ref.4).
CC       {ECO:0000269|PubMed:17138696, ECO:0000269|Ref.4}.
CC   -!- INDUCTION: Expression regulated by iron through the urbs1 transcription
CC       factor (PubMed:17138696). {ECO:0000269|PubMed:17138696}.
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DR   EMBL; CM003141; KIS71536.1; -; Genomic_DNA.
DR   EMBL; BK004083; DAA04934.1; -; Genomic_DNA.
DR   RefSeq; XP_011387440.1; XM_011389138.1.
DR   AlphaFoldDB; A1A653; -.
DR   SMR; A1A653; -.
DR   STRING; 237631.A1A653; -.
DR   EnsemblFungi; KIS71536; KIS71536; UMAG_11338.
DR   GeneID; 23567234; -.
DR   KEGG; uma:UMAG_11338; -.
DR   VEuPathDB; FungiDB:UMAG_11338; -.
DR   OrthoDB; 1463391at2759; -.
DR   Proteomes; UP000000561; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004174; F:electron-transferring-flavoprotein dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Virulence.
FT   CHAIN           1..398
FT                   /note="Fe-regulated protein 8"
FT                   /id="PRO_0000441964"
SQ   SEQUENCE   398 AA;  44171 MW;  1C6AEB4F6C955F95 CRC64;
     MTIDLSLKSN QQKTIAVLGA SYAGHRAIQV LVASLPEDWR VVVLERNTHA NHLYAFPRMS
     VVRGHEQKVF IPYTNMFKPA LDRRDQHVLL HANVLELDQE QRRVSYELID DKQSGVQWLH
     WDFLVYALGS HLPDPINVWS NSEHVNTHDG SKMMGVKWLR DAQDRIEKAE SIVIVGGGAL
     GVQLATDIAV TYGSSKKVTL THSRPQLLPR FDPWMHEKTA ARLQELGVEL ALGSRVDLST
     VSEDKKRFKL LDGRELQGDL TLFCLGQTPN TSLLGASSLN DSGMAKVEPT LQLSANERIF
     VIGDAADAFG AINAGHTAWD QAEVAAKNIL ALIDNKGQAM KLEEYKPTPP AIKVSLGIDR
     AIRQTMAGEL VEVDSGSIDL NSTNMWTRRG LSTDDLWQ