FER_SULAC
ID FER_SULAC Reviewed; 103 AA.
AC P00219; Q4JBG2;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Zinc-containing ferredoxin;
GN Name=zfx; OrderedLocusNames=Saci_0456;
OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS 15157 / NCIMB 11770).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=330779;
RN [1]
RP PROTEIN SEQUENCE, AND METHYLATION AT LYS-29.
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=3926756; DOI=10.1093/oxfordjournals.jbchem.a135114;
RA Minami Y., Wakabayashi S., Wada K., Matsubara H., Kerscher L.,
RA Oesterhelt D.;
RT "Amino acid sequence of a ferredoxin from thermoacidophilic
RT archaebacterium, Sulfolobus acidocaldarius. Presence of an N6-
RT monomethyllysine and phyletic consideration of archaebacteria.";
RL J. Biochem. 97:745-753(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT "The genome of Sulfolobus acidocaldarius, a model organism of the
RT Crenarchaeota.";
RL J. Bacteriol. 187:4992-4999(2005).
RN [3]
RP PROTEIN SEQUENCE OF 1-30, AND PRESENCE OF A 3FE-4S AND A 4FE-4S CLUSTER.
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=8521862; DOI=10.1111/j.1432-1033.1995.937_3.x;
RA Breton J.L., Duff J.L., Butt J.N., Armstrong F.A., George S.J.,
RA Petillot Y., Forest E., Schafer G., Thomson A.J.;
RT "Identification of the iron-sulfur clusters in a ferredoxin from the
RT archaeon Sulfolobus acidocaldarius. Evidence for a reduced [3Fe-4S] cluster
RT with pH-dependent electronic properties.";
RL Eur. J. Biochem. 233:937-946(1995).
CC -!- FUNCTION: Ferredoxins are iron-sulfur proteins that transfer electrons
CC in a wide variety of metabolic reactions.
CC -!- COFACTOR:
CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000250};
CC Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 1 zinc ion. {ECO:0000250};
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DR EMBL; CP000077; AAY79867.1; -; Genomic_DNA.
DR PIR; A00223; FEUC.
DR AlphaFoldDB; P00219; -.
DR SMR; P00219; -.
DR STRING; 330779.Saci_0456; -.
DR iPTMnet; P00219; -.
DR EnsemblBacteria; AAY79867; AAY79867; Saci_0456.
DR KEGG; sai:Saci_0456; -.
DR PATRIC; fig|330779.12.peg.454; -.
DR eggNOG; arCOG04548; Archaea.
DR HOGENOM; CLU_178207_0_0_2; -.
DR OMA; QFHENRD; -.
DR Proteomes; UP000001018; Chromosome.
DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009157; Fd_Zn-bd.
DR Pfam; PF13237; Fer4_10; 1.
DR PIRSF; PIRSF000068; Zn_Fdx_Sulfol; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 1: Evidence at protein level;
KW 3Fe-4S; 4Fe-4S; Direct protein sequencing; Electron transport; Iron;
KW Iron-sulfur; Metal-binding; Methylation; Reference proteome; Repeat;
KW Transport; Zinc.
FT CHAIN 1..103
FT /note="Zinc-containing ferredoxin"
FT /id="PRO_0000159177"
FT DOMAIN 35..65
FT /note="4Fe-4S ferredoxin-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT DOMAIN 74..103
FT /note="4Fe-4S ferredoxin-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT REGION 1..36
FT /note="N-terminal extension"
FT BINDING 19
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 45
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT BINDING 51
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT BINDING 55
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 83
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250"
FT BINDING 86
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250"
FT BINDING 89
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250"
FT BINDING 93
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT /evidence="ECO:0000250"
FT MOD_RES 29
FT /note="N6-methyllysine"
FT /evidence="ECO:0000269|PubMed:3926756"
FT CONFLICT 9
FT /note="S -> H (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 16
FT /note="H -> S (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 80
FT /note="E -> Q (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 103 AA; 10893 MW; 6AD0900817C1A4D3 CRC64;
GIDPNYRTSK PVVGDHSGHK IYGPVESPKV LGVHGTIVGV DFDLCIADGS CITACPVNVF
QWYETPGHPA SEKKADPVNE QACIFCMACV NVCPVAAIDV KPP
