FER_THET8
ID FER_THET8 Reviewed; 79 AA.
AC P03942; Q5SLW6;
DT 23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Ferredoxin;
GN OrderedLocusNames=TTHA0177;
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 2-79.
RX PubMed=7225412; DOI=10.1016/0005-2795(81)90035-0;
RA Sato S., Nakazawa K., Hon-Nami K., Oshima T.;
RT "Purification, some properties and amino acid sequence of Thermus
RT thermophilus HB8 ferredoxin.";
RL Biochim. Biophys. Acta 668:277-289(1981).
RN [3]
RP PROTEIN SEQUENCE OF 2-79, AND X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS).
RX PubMed=11681700; DOI=10.1007/s007750100243;
RA Macedo-Ribeiro S., Martins B.M., Pereira P.J., Buse G., Huber R.,
RA Soulimane T.;
RT "New insights into the thermostability of bacterial ferredoxins: high-
RT resolution crystal structure of the seven-iron ferredoxin from Thermus
RT thermophilus.";
RL J. Biol. Inorg. Chem. 6:663-674(2001).
RN [4]
RP AMINO-ACID COMPOSITION.
RC STRAIN=ATCC 696;
RX PubMed=6313685; DOI=10.1016/s0021-9258(17)44072-5;
RA Hille R., Yoshida T., Tarr G.E., Williams C.H. Jr., Ludwig M.I., Fee J.A.,
RA Kent T.A., Huynh B.H., Munck E.;
RT "Studies of the ferredoxin from Thermus thermophilus.";
RL J. Biol. Chem. 258:13008-13013(1983).
CC -!- FUNCTION: Ferredoxins are iron-sulfur proteins that transfer electrons
CC in a wide variety of metabolic reactions.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Note=Binds 1 [4Fe-4S] cluster.;
CC -!- COFACTOR:
CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC Note=Binds 1 [3Fe-4S] cluster.;
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DR EMBL; AP008226; BAD70000.1; -; Genomic_DNA.
DR PIR; A00216; FETWT.
DR RefSeq; WP_008630832.1; NC_006461.1.
DR RefSeq; YP_143443.1; NC_006461.1.
DR PDB; 1H98; X-ray; 1.64 A; A=2-79.
DR PDBsum; 1H98; -.
DR AlphaFoldDB; P03942; -.
DR SMR; P03942; -.
DR STRING; 300852.55771559; -.
DR EnsemblBacteria; BAD70000; BAD70000; BAD70000.
DR GeneID; 3169609; -.
DR KEGG; ttj:TTHA0177; -.
DR PATRIC; fig|300852.9.peg.175; -.
DR eggNOG; COG1146; Bacteria.
DR HOGENOM; CLU_139698_0_1_0; -.
DR OMA; DRMLYIH; -.
DR PhylomeDB; P03942; -.
DR EvolutionaryTrace; P03942; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR000813; 7Fe_ferredoxin.
DR Pfam; PF00037; Fer4; 1.
DR PRINTS; PR00354; 7FE8SFRDOXIN.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; 3Fe-4S; 4Fe-4S; Direct protein sequencing;
KW Electron transport; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW Repeat; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:11681700,
FT ECO:0000269|PubMed:7225412"
FT CHAIN 2..79
FT /note="Ferredoxin"
FT /id="PRO_0000159108"
FT DOMAIN 2..30
FT /note="4Fe-4S ferredoxin-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT DOMAIN 31..60
FT /note="4Fe-4S ferredoxin-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT BINDING 9
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT BINDING 17
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT BINDING 21
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT BINDING 40
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT BINDING 43
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT BINDING 46
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT BINDING 50
FT /ligand="[3Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:21137"
FT CONFLICT 7
FT /note="E -> Q (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT STRAND 3..5
FT /evidence="ECO:0007829|PDB:1H98"
FT HELIX 7..9
FT /evidence="ECO:0007829|PDB:1H98"
FT TURN 10..12
FT /evidence="ECO:0007829|PDB:1H98"
FT HELIX 16..20
FT /evidence="ECO:0007829|PDB:1H98"
FT STRAND 26..28
FT /evidence="ECO:0007829|PDB:1H98"
FT STRAND 30..35
FT /evidence="ECO:0007829|PDB:1H98"
FT TURN 37..39
FT /evidence="ECO:0007829|PDB:1H98"
FT HELIX 46..49
FT /evidence="ECO:0007829|PDB:1H98"
FT STRAND 55..57
FT /evidence="ECO:0007829|PDB:1H98"
FT HELIX 58..60
FT /evidence="ECO:0007829|PDB:1H98"
FT HELIX 63..66
FT /evidence="ECO:0007829|PDB:1H98"
FT HELIX 67..75
FT /evidence="ECO:0007829|PDB:1H98"
SQ SEQUENCE 79 AA; 8818 MW; 33BB84B159BC10A6 CRC64;
MPHVICEPCI GVKDQSCVEV CPVECIYDGG DQFYIHPEEC IDCGACVPAC PVNAIYPEED
VPEQWKSYIE KNRKLAGLE
