ID   FER_TRIVA               Reviewed;         100 AA.
AC   P21149;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Ferredoxin;
DE   Flags: Precursor;
OS   Trichomonas vaginalis.
OC   Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC   Trichomonas.
OX   NCBI_TaxID=5722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 9-100.
RC   STRAIN=ATCC 30001 / NIH-C1;
RX   PubMed=1696716; DOI=10.1073/pnas.87.16.6097;
RA   Johnson P.J., D'Oliveira C.E., Gorrell T.E., Mueller M.;
RT   "Molecular analysis of the hydrogenosomal ferredoxin of the anaerobic
RT   protist Trichomonas vaginalis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:6097-6101(1990).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 9-100.
RX   PubMed=12051855; DOI=10.1016/s0022-2836(02)00051-7;
RA   Crossnoe C.R., Germanas J.P., LeMagueres P., Mustata G., Krause K.L.;
RT   "The crystal structure of Trichomonas vaginalis ferredoxin provides insight
RT   into metronidazole activation.";
RL   J. Mol. Biol. 318:503-518(2002).
CC   -!- FUNCTION: Ferredoxins are iron-sulfur proteins that transfer electrons
CC       in a wide variety of metabolic reactions. It links pyruvate:ferredoxin
CC       oxidoreductase to hydrogenase.
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC       Note=Binds 1 [2Fe-2S] cluster.;
CC   -!- SUBCELLULAR LOCATION: Hydrogenosome.
CC   -!- MISCELLANEOUS: The propeptide may play a role in the targeting of this
CC       protein to the organelle.
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DR   EMBL; M33717; AAA30324.1; -; Genomic_DNA.
DR   PIR; A36003; A36003.
DR   PDB; 1L5P; X-ray; 2.20 A; A/B/C=9-100.
DR   PDBsum; 1L5P; -.
DR   AlphaFoldDB; P21149; -.
DR   SMR; P21149; -.
DR   VEuPathDB; TrichDB:TVAG_003900; -.
DR   EvolutionaryTrace; P21149; -.
DR   GO; GO:0042566; C:hydrogenosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   Pfam; PF00111; Fer2; 1.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
PE   1: Evidence at protein level;
KW   2Fe-2S; 3D-structure; Direct protein sequencing; Electron transport;
KW   Hydrogenosome; Iron; Iron-sulfur; Metal-binding; Transport.
FT   PROPEP          1..8
FT                   /evidence="ECO:0000269|PubMed:1696716"
FT                   /id="PRO_0000008841"
FT   CHAIN           9..100
FT                   /note="Ferredoxin"
FT                   /id="PRO_0000008842"
FT   DOMAIN          9..100
FT                   /note="2Fe-2S ferredoxin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         46
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   BINDING         52
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   BINDING         55
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   BINDING         85
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   STRAND          10..15
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   STRAND          18..23
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   HELIX           30..35
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   TURN            36..38
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   STRAND          47..52
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   STRAND          56..62
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   HELIX           68..74
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   STRAND          81..83
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   HELIX           84..86
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   HELIX           91..93
FT                   /evidence="ECO:0007829|PDB:1L5P"
FT   STRAND          97..99
FT                   /evidence="ECO:0007829|PDB:1L5P"
SQ   SEQUENCE   100 AA;  10675 MW;  66ADB3EDAD3F4773 CRC64;
     MLSQVCRFGT ITAVKGGVKK QLKFEDDQTL FTVLTEAGLM SADDTCQGNK ACGKCICKHV
     SGKVAAEDDE KEFLEDQPAN ARLACAITLS GENDGAVFEL