FES1_ASHGO
ID FES1_ASHGO Reviewed; 289 AA.
AC Q75B89;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN Name=FES1; OrderedLocusNames=ADL319W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC chaperones which accelerates the release of ADP. Required for fully
CC efficient Hsp70-mediated folding of proteins (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR EMBL; AE016817; AAS51601.1; -; Genomic_DNA.
DR RefSeq; NP_983777.1; NM_209130.1.
DR AlphaFoldDB; Q75B89; -.
DR SMR; Q75B89; -.
DR STRING; 33169.AAS51601; -.
DR EnsemblFungi; AAS51601; AAS51601; AGOS_ADL319W.
DR GeneID; 4619912; -.
DR KEGG; ago:AGOS_ADL319W; -.
DR eggNOG; KOG2160; Eukaryota.
DR HOGENOM; CLU_046722_1_0_1; -.
DR InParanoid; Q75B89; -.
DR OMA; LHWSIAN; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR Pfam; PF08609; Fes1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT CHAIN 1..289
FT /note="Hsp70 nucleotide exchange factor FES1"
FT /id="PRO_0000285383"
FT REPEAT 13..56
FT /note="ARM 1"
FT REPEAT 75..114
FT /note="ARM 2"
FT REPEAT 118..159
FT /note="ARM 3"
FT REPEAT 162..203
FT /note="ARM 4"
FT REPEAT 222..267
FT /note="ARM 5"
SQ SEQUENCE 289 AA; 32025 MW; 85A4CF1627EEDBA5 CRC64;
MDKLLHWSIA NAQGDKEAAA KAGAPDPKLL QQLFGGGPDE PALMRDAMAV IMNPEATVDN
KLVAFDNFEM LIENLDNANN IENMRLWAPL ISILESEEEQ LRECALSVVG TAVQNNEKSQ
SNFLKHDGAM KKIIELARKD SESEQVRTKA FYALSNIVRH NKDASALFVD NGGLEIMAPV
LKHQNTGEKM KIRALALLTS VLTSLSADEK FSDRIREDKI LEASLEHLAP SANPYLIDRV
LNLLVLMKGS GAKFDTDELS KIRKSFASLY PVKDQLNEDD YNAVKEMLG
