FES1_ASPNC
ID FES1_ASPNC Reviewed; 287 AA.
AC A2R4I6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Hsp70 nucleotide exchange factor fes1;
GN Name=fes1; ORFNames=An15g00550;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC chaperones which accelerates the release of ADP. Required for fully
CC efficient Hsp70-mediated folding of proteins (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR EMBL; AM270330; CAK42224.1; -; Genomic_DNA.
DR AlphaFoldDB; A2R4I6; -.
DR SMR; A2R4I6; -.
DR PaxDb; A2R4I6; -.
DR EnsemblFungi; CAK42224; CAK42224; An15g00550.
DR VEuPathDB; FungiDB:An15g00550; -.
DR HOGENOM; CLU_084507_0_0_1; -.
DR Proteomes; UP000006706; Chromosome 3R.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR Pfam; PF08609; Fes1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT CHAIN 1..287
FT /note="Hsp70 nucleotide exchange factor fes1"
FT /id="PRO_0000285385"
FT REPEAT 32..73
FT /note="ARM 1"
FT REPEAT 92..131
FT /note="ARM 2"
FT REPEAT 134..174
FT /note="ARM 3"
FT REPEAT 192..231
FT /note="ARM 4"
FT REGION 16..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 31363 MW; C7F5A0A8C7C75F40 CRC64;
MDPNMNSLLK WSIKAATEEQ SSGENNNNNN SGNNAPADPS RGLTPQMLST LFGGPSEADL
MKAAMEALRS DEVDLENKLI AFDNFEQLIE SIDNANNLEP LGLWTPLVEL LDHKEPDMRR
MAAWCIGTAV QNNEKAQDKL IVLNALPKLV SLATADTTPV VRKKAVYAIS SAVRNYQPAM
DEVTKSLPEG YSRDKIDAGD MDAVDALMDK LRAHKPTFVT CTVDRMLSPS KPTSSSSGEH
VVPLRGTRAL RVDRARALTM LASGRHAVTG TRLSYEAQAI RPHLIPK
