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FES1_ASPOR
ID   FES1_ASPOR              Reviewed;         216 AA.
AC   Q2U9E2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Hsp70 nucleotide exchange factor fes1;
GN   Name=fes1; ORFNames=AO090701000063;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; AP007164; BAE61823.1; -; Genomic_DNA.
DR   RefSeq; XP_001822956.1; XM_001822904.2.
DR   AlphaFoldDB; Q2U9E2; -.
DR   SMR; Q2U9E2; -.
DR   STRING; 510516.Q2U9E2; -.
DR   EnsemblFungi; BAE61823; BAE61823; AO090701000063.
DR   GeneID; 5995013; -.
DR   KEGG; aor:AO090701000063; -.
DR   VEuPathDB; FungiDB:AO090701000063; -.
DR   HOGENOM; CLU_084507_0_0_1; -.
DR   OMA; MEPLGLW; -.
DR   Proteomes; UP000006564; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR   GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..216
FT                   /note="Hsp70 nucleotide exchange factor fes1"
FT                   /id="PRO_0000285386"
FT   REPEAT          27..68
FT                   /note="ARM 1"
FT   REPEAT          87..126
FT                   /note="ARM 2"
FT   REPEAT          129..169
FT                   /note="ARM 3"
FT   REGION          16..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  23558 MW;  9CF64020C9CC727E CRC64;
     MDANMNNLLK WSIQNSTTQQ SDAPNASNNT ADSSARGLTP EMLSALFGGP SDADLMKAAM
     EALHSDEVDL ENKLIAFDNF EQLIESIDNA NNLEPLGLWT PLVELLQHEE AEMRRMAAWC
     IGTAVQNNEK AQDKLVVFNA VPKLVTMSTT DSNPATRKKA VFALSSAVRN YQPAMDELVK
     HLPEGYSQGE KVDAGDMDAV DAIMDRLRAH PVPSSA
 
 
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