ID   FES1_ASPTN              Reviewed;         212 AA.
AC   Q0CH70;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Hsp70 nucleotide exchange factor fes1;
GN   Name=fes1; ORFNames=ATEG_06972;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; CH476603; EAU32356.1; -; Genomic_DNA.
DR   RefSeq; XP_001209658.1; XM_001209658.1.
DR   AlphaFoldDB; Q0CH70; -.
DR   SMR; Q0CH70; -.
DR   STRING; 341663.Q0CH70; -.
DR   EnsemblFungi; EAU32356; EAU32356; ATEG_06972.
DR   GeneID; 4318895; -.
DR   VEuPathDB; FungiDB:ATEG_06972; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_084507_0_0_1; -.
DR   OMA; MEPLGLW; -.
DR   OrthoDB; 1310125at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR   GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..212
FT                   /note="Hsp70 nucleotide exchange factor fes1"
FT                   /id="PRO_0000285387"
FT   REPEAT          23..64
FT                   /note="ARM 1"
FT   REPEAT          83..122
FT                   /note="ARM 2"
FT   REPEAT          125..165
FT                   /note="ARM 3"
SQ   SEQUENCE   212 AA;  23088 MW;  FA55514B6822D6F5 CRC64;
     MDANMNKILK WSIQNSTNAS SDQNAAADAT SRGLTPEMMA TLFGGPSDAD LMKASMEALR
     SDEVDLENKL VAFDNFEQLI ESIDNANNLE PLGLWTPLVE LLRHEEADMR RMAAWCVGTA
     VQNNEKAQDK LVVLNALPTL VAMSTSDPNP AARKKAVYAL SSAVRNYQPA MDEVAKHLPE
     GYPRGEKIDA ADMDAVDGIM DKLRAHPVES SA