ID   FES1_CHAGB              Reviewed;         267 AA.
AC   Q2GXZ7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; ORFNames=CHGG_07157;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; CH408033; EAQ85904.1; -; Genomic_DNA.
DR   RefSeq; XP_001224813.1; XM_001224812.1.
DR   AlphaFoldDB; Q2GXZ7; -.
DR   SMR; Q2GXZ7; -.
DR   STRING; 38033.XP_001224813.1; -.
DR   EnsemblFungi; EAQ85904; EAQ85904; CHGG_07157.
DR   GeneID; 4394355; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_084507_0_0_1; -.
DR   InParanoid; Q2GXZ7; -.
DR   OMA; MEPLGLW; -.
DR   OrthoDB; 1310125at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..267
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285390"
FT   REPEAT          58..99
FT                   /note="ARM 1"
FT   REPEAT          118..157
FT                   /note="ARM 2"
FT   REPEAT          160..201
FT                   /note="ARM 3"
FT   REGION          17..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   267 AA;  28344 MW;  90295D29146D560E CRC64;
     MERNLNSLLK WSIENSVPSS APAANGTNGT NGTTAVTTHS SDSNNTSTTP ADAPSQTNGT
     SAAAANSKLN PEILSALFGG PSEAELMKAA MEVLTDKSAT LDNQLIAFDN FEQLIESLDN
     ANNLEPLKLW APLLGLLAHD EAEMRRMAAW CVGTAVQNNA RTQERLLAEG GLPILVGLAT
     KEGEDVAVRR KAIYALSSAV RNCQPAMDAA TAELSAHGKG DKVDAGDMDA VDGVIEWLRG
     EGERCVNGVK TFYDVGIGYQ RRREERG