ID   FES1_COCIM              Reviewed;         212 AA.
AC   Q1E3S4; I9XID8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; ORFNames=CIMG_02789;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG704911; EAS37435.3; -; Genomic_DNA.
DR   RefSeq; XP_001249018.2; XM_001249017.2.
DR   AlphaFoldDB; Q1E3S4; -.
DR   SMR; Q1E3S4; -.
DR   STRING; 246410.Q1E3S4; -.
DR   EnsemblFungi; EAS37435; EAS37435; CIMG_02789.
DR   GeneID; 4566529; -.
DR   KEGG; cim:CIMG_02789; -.
DR   VEuPathDB; FungiDB:CIMG_02789; -.
DR   InParanoid; Q1E3S4; -.
DR   OMA; MEPLGLW; -.
DR   OrthoDB; 1310125at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..212
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285391"
FT   REPEAT          26..67
FT                   /note="ARM 1"
FT   REPEAT          86..125
FT                   /note="ARM 2"
FT   REPEAT          128..168
FT                   /note="ARM 3"
SQ   SEQUENCE   212 AA;  23665 MW;  367E7EB036BAEDA3 CRC64;
     MDSHMNNLLK WSIENSVPAQ PDDPEQVKQE RSLDRLDTQA LQRLLSNAPS DADLMKAAME
     VVSDDFATLE NKLIAFDNFE QLIENLDNAN NMGVLGLWTP LVEALSDAEP QMRKMAAWCI
     GTAVQNNEMA QNKLLDFKAV PKLLSLAKTD PDTTVRRKAI YALSSAVRNH QPSLDELQKL
     LPADYVSEGE KMNAADMDRI DAIMNKLKEI PA