FES1_CRYNB
ID FES1_CRYNB Reviewed; 379 AA.
AC P0CN69; Q55TX8; Q5KIG0;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN Name=FES1; OrderedLocusNames=CNBD3250;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC chaperones which accelerates the release of ADP. Required for fully
CC efficient Hsp70-mediated folding of proteins (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR EMBL; AAEY01000020; EAL21271.1; -; Genomic_DNA.
DR RefSeq; XP_775918.1; XM_770825.1.
DR AlphaFoldDB; P0CN69; -.
DR SMR; P0CN69; -.
DR EnsemblFungi; AAW43373; AAW43373; CND03100.
DR EnsemblFungi; EAL21271; EAL21271; CNBD3250.
DR GeneID; 4935714; -.
DR KEGG; cnb:CNBD3250; -.
DR VEuPathDB; FungiDB:CNBD3250; -.
DR HOGENOM; CLU_046722_0_0_1; -.
DR Proteomes; UP000001435; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR Pfam; PF08609; Fes1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Repeat; Translation regulation.
FT CHAIN 1..379
FT /note="Hsp70 nucleotide exchange factor FES1"
FT /id="PRO_0000410089"
FT REPEAT 25..114
FT /note="ARM 1"
FT REPEAT 133..172
FT /note="ARM 2"
FT REPEAT 175..220
FT /note="ARM 3"
FT REGION 29..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 41537 MW; 87F50038AB6A09E1 CRC64;
MPDINELLRW SIANSTAPDT DASEQLQIRF NPNSTQSGTS TLHASDSGPP DISPASTPGP
VTPDDGSSLP LPPGTEVPVT KKEDLTTEML DLILGKGDSI TMKEKMAFAT DENNSVEDRV
EALDDFEMLI ELIDNANNMP ILKLWDPLLT LLSSSHPEIV AHTCWIIGTA IQNNIKAQAA
FYIHETFSRI LEIIYPPSSI SSYPPSVRAK ATYALSAALK HWPLASYALY TATSSAENGY
SVLRRGVNDP QAIVRRKMAF LVGTLAMQSG ERYEGEIPSE VRNYIEENEK NAPSESLVEG
LKREGVFTAL VDGLKQGVDD VEYEENAMRA LVRAHQKGGL TVSEKSDLKT IWEKWGKQGR
QERGLDGEDG KEVSETLSS