ID   FES1_CRYNJ              Reviewed;         379 AA.
AC   P0CN68; Q55TX8; Q5KIG0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; OrderedLocusNames=CND03100;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; AE017344; AAW43373.1; -; Genomic_DNA.
DR   RefSeq; XP_570680.1; XM_570680.1.
DR   AlphaFoldDB; P0CN68; -.
DR   SMR; P0CN68; -.
DR   STRING; 5207.AAW43373; -.
DR   PaxDb; P0CN68; -.
DR   EnsemblFungi; AAW43373; AAW43373; CND03100.
DR   GeneID; 3257451; -.
DR   KEGG; cne:CND03100; -.
DR   VEuPathDB; FungiDB:CND03100; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_046722_0_0_1; -.
DR   InParanoid; P0CN68; -.
DR   OMA; WAVENTD; -.
DR   OrthoDB; 1310125at2759; -.
DR   Proteomes; UP000002149; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..379
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285392"
FT   REPEAT          25..114
FT                   /note="ARM 1"
FT   REPEAT          133..172
FT                   /note="ARM 2"
FT   REPEAT          175..220
FT                   /note="ARM 3"
FT   REGION          29..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   379 AA;  41537 MW;  87F50038AB6A09E1 CRC64;
     MPDINELLRW SIANSTAPDT DASEQLQIRF NPNSTQSGTS TLHASDSGPP DISPASTPGP
     VTPDDGSSLP LPPGTEVPVT KKEDLTTEML DLILGKGDSI TMKEKMAFAT DENNSVEDRV
     EALDDFEMLI ELIDNANNMP ILKLWDPLLT LLSSSHPEIV AHTCWIIGTA IQNNIKAQAA
     FYIHETFSRI LEIIYPPSSI SSYPPSVRAK ATYALSAALK HWPLASYALY TATSSAENGY
     SVLRRGVNDP QAIVRRKMAF LVGTLAMQSG ERYEGEIPSE VRNYIEENEK NAPSESLVEG
     LKREGVFTAL VDGLKQGVDD VEYEENAMRA LVRAHQKGGL TVSEKSDLKT IWEKWGKQGR
     QERGLDGEDG KEVSETLSS