FES1_DEBHA
ID FES1_DEBHA Reviewed; 284 AA.
AC Q6BLA1;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN Name=FES1; OrderedLocusNames=DEHA2F15180g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC chaperones which accelerates the release of ADP. Required for fully
CC efficient Hsp70-mediated folding of proteins (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR EMBL; CR382138; CAG89390.2; -; Genomic_DNA.
DR RefSeq; XP_461020.2; XM_461020.1.
DR AlphaFoldDB; Q6BLA1; -.
DR SMR; Q6BLA1; -.
DR STRING; 4959.XP_461020.2; -.
DR PRIDE; Q6BLA1; -.
DR EnsemblFungi; CAG89390; CAG89390; DEHA2F15180g.
DR GeneID; 2904141; -.
DR KEGG; dha:DEHA2F15180g; -.
DR VEuPathDB; FungiDB:DEHA2F15180g; -.
DR eggNOG; KOG2160; Eukaryota.
DR HOGENOM; CLU_046722_1_0_1; -.
DR InParanoid; Q6BLA1; -.
DR OMA; LHWSIAN; -.
DR OrthoDB; 1310125at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR Pfam; PF08609; Fes1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT CHAIN 1..284
FT /note="Hsp70 nucleotide exchange factor FES1"
FT /id="PRO_0000285393"
FT REPEAT 13..55
FT /note="ARM 1"
FT REPEAT 117..158
FT /note="ARM 2"
FT REPEAT 161..199
FT /note="ARM 3"
FT REPEAT 204..244
FT /note="ARM 4"
SQ SEQUENCE 284 AA; 31833 MW; 1203014DA6F9F946 CRC64;
MDKLLQWSIA QQSGDQEAIE KIGKPDPKML EQLFGGPDEP ALMKQAIMVI DNEEATLENR
EIAFDNFEML IENMDNANNI ENIKLWQSVI DKMSAETPTS LRVYAASCAG IAVQNNPKSQ
EDFLKYDGLA SLISICNEED VPTELRLKAL FAISSLIRNF EVGYAKFDEL DGWSVVKFNE
NEDHKVKLRI LSLVSAILST PLDKKKEEHV HREKLVANII SILKKDGHIG CIDKALNIIS
QLASSEFEFS SSEIGDIAQG LEEIEKLKDS ISEDDYNSVK QVVN
