ID   FES1_KLULA              Reviewed;         289 AA.
AC   Q6CNM7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; OrderedLocusNames=KLLA0E11341g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382125; CAG99549.1; -; Genomic_DNA.
DR   RefSeq; XP_454462.1; XM_454462.1.
DR   AlphaFoldDB; Q6CNM7; -.
DR   SMR; Q6CNM7; -.
DR   STRING; 28985.XP_454462.1; -.
DR   EnsemblFungi; CAG99549; CAG99549; KLLA0_E11375g.
DR   GeneID; 2893735; -.
DR   KEGG; kla:KLLA0_E11375g; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_046722_1_0_1; -.
DR   InParanoid; Q6CNM7; -.
DR   OMA; LHWSIAN; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR   GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..289
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285396"
FT   REPEAT          13..56
FT                   /note="ARM 1"
FT   REPEAT          75..114
FT                   /note="ARM 2"
FT   REPEAT          118..159
FT                   /note="ARM 3"
FT   REPEAT          162..203
FT                   /note="ARM 4"
FT   REPEAT          209..249
FT                   /note="ARM 5"
SQ   SEQUENCE   289 AA;  32375 MW;  5262ABBD824EAC6B CRC64;
     MEKLLHWSIA NAQGDDEAKA RAGQPDPKLL EQLFGGGPDE PTLMKHAMAV ISNPEATLEN
     KLVAFDNFEM LIENLDNANN IENMKLWEPL ITVLDDPEPE LRAFALSVTG TAVQNNDQSQ
     NNFAKYDGAL AKVIKLASGR AEDAQVRTKA FYTLSNLIRH NKLIYDQFNQ LNGLQIIAPV
     LKDANASEKL KLRAMALLST VLTVADMNAD FFALLRAYNI IETTLEFLHP ECNLYLIDRV
     LNFFSQLINV GFEFSATELE KLKVGVKNIE PVEAQLNEDD YKTVQYVSK