ID   FES1_NEOFI              Reviewed;         216 AA.
AC   A1DLW4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Hsp70 nucleotide exchange factor fes1;
GN   Name=fes1; ORFNames=NFIA_051300;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW15785.1; -; Genomic_DNA.
DR   RefSeq; XP_001257682.1; XM_001257681.1.
DR   AlphaFoldDB; A1DLW4; -.
DR   SMR; A1DLW4; -.
DR   STRING; 36630.CADNFIAP00004631; -.
DR   EnsemblFungi; EAW15785; EAW15785; NFIA_051300.
DR   GeneID; 4584197; -.
DR   KEGG; nfi:NFIA_051300; -.
DR   VEuPathDB; FungiDB:NFIA_051300; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_084507_0_0_1; -.
DR   OMA; MEPLGLW; -.
DR   OrthoDB; 1310125at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR   GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..216
FT                   /note="Hsp70 nucleotide exchange factor fes1"
FT                   /id="PRO_0000285397"
FT   REPEAT          27..68
FT                   /note="ARM 1"
FT   REPEAT          87..126
FT                   /note="ARM 2"
FT   REPEAT          129..169
FT                   /note="ARM 3"
FT   REPEAT          185..216
FT                   /note="ARM 4"
FT   REGION          19..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  23571 MW;  6AB12B587A2E5D4B CRC64;
     MDPNMNNLLK WSIENSTSAR QAADSNDAAP APTSRSNLNP EMLSALFGGP SDADLMKAAM
     EALHSDEVDL ENKMIAFDNF EQLIESIDNA NNLEPLGLWT PLVELLKHEE AEMRRMAAWC
     IGTAVQNNEK AQDKLIVFNV LPTLVAMSTS DPAPAARKKA VYAISSGVRN YQPAMDEFVK
     HLPEGYTSGE KIDAADMDAI DALLDKLRAH PSEVSA