ID   FES1_PICST              Reviewed;         284 AA.
AC   A3LUY1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; ORFNames=PICST_46950;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; CP000499; ABN67034.1; -; Genomic_DNA.
DR   RefSeq; XP_001385063.1; XM_001385026.1.
DR   AlphaFoldDB; A3LUY1; -.
DR   SMR; A3LUY1; -.
DR   STRING; 4924.XP_001385063.1; -.
DR   EnsemblFungi; ABN67034; ABN67034; PICST_46950.
DR   GeneID; 4839602; -.
DR   KEGG; pic:PICST_46950; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_046722_1_0_1; -.
DR   InParanoid; A3LUY1; -.
DR   OMA; LHWSIAN; -.
DR   OrthoDB; 1310125at2759; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..284
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285400"
FT   REPEAT          13..55
FT                   /note="ARM 1"
FT   REPEAT          74..114
FT                   /note="ARM 2"
FT   REPEAT          117..158
FT                   /note="ARM 3"
FT   REPEAT          161..199
FT                   /note="ARM 4"
FT   REPEAT          204..244
FT                   /note="ARM 5"
SQ   SEQUENCE   284 AA;  31656 MW;  3B985A60A724C062 CRC64;
     MDKLLQWSIA QQSGDKEAIQ KLGQPDPKML EQLFGGPDEP TLMKQAIAVI QNPEATLEDK
     EIAFDNFEML IENLDNANNI ENMKLWPAIV NQLEDGVPAT LRVYAASVIG TAVQNNPKAQ
     EDFNKTSGPE KLIKIASDEK TPKDLLLKTL YALSSAMRNF KPAYANFVEN NGWNIISLSK
     ENDHKIQLRQ LSAVSSILST GLDEDKQENI QNAKLVEYLV SILTKDGHIG CIEKALNIIS
     ELAHYKYQFT STEIARLAQG LEQIETLSDR LTEEDLVSAK KIVS