ID   FES1_USTMA              Reviewed;         389 AA.
AC   Q4P7F2; A0A0D1DZF0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; ORFNames=UMAG_11735;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; CM003150; KIS67910.1; -; Genomic_DNA.
DR   RefSeq; XP_011390573.1; XM_011392271.1.
DR   AlphaFoldDB; Q4P7F2; -.
DR   SMR; Q4P7F2; -.
DR   STRING; 5270.UM03961P0; -.
DR   EnsemblFungi; KIS67910; KIS67910; UMAG_11735.
DR   GeneID; 23567586; -.
DR   KEGG; uma:UMAG_11735; -.
DR   VEuPathDB; FungiDB:UMAG_11735; -.
DR   HOGENOM; CLU_046722_0_1_1; -.
DR   InParanoid; Q4P7F2; -.
DR   OrthoDB; 1310125at2759; -.
DR   Proteomes; UP000000561; Chromosome 11.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..389
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285402"
FT   REPEAT          95..134
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          137..176
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          179..218
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          268..310
FT                   /note="ARM 4"
FT                   /evidence="ECO:0000255"
FT   REGION          223..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  41909 MW;  B49BB1778ED00A4E CRC64;
     MSNDRNAQEL LKWGLANSGS TGVASFASQS VEQISADIEA GRRPDLADPN LYNAIMGKSE
     AQMMAEELSV AIDTSRTLPD RMTALDNFEM LIEQIDNANN MTSMKMWSPI ISLLSAPEAE
     IQTAAAWIIG TAVQNNDKAQ MAVLDFHPVA ALLDLLHSHV DEVRAKAMYA LSGLLKHNPA
     AMHQFDQLDG WNMLNMALVD PNLGLRRKTA FLINALLLQD PNSLDSQPAS TSTATAIAPV
     SFTPPTPTAP PAPLERGPET LRTSIPHPNV ARALVQSNII NTLISSLLPA HTLPDTLSPP
     PTGANGDSDA RLDLDFAEKS AAAILTFTTK LPPSPSHPLD PTTISLFKAL LVQLQAKPLD
     SSDPASTRWA ELGIHAHDFD QFKHKIHAL