ID   FES1_YARLI              Reviewed;         280 AA.
AC   Q6C239;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; OrderedLocusNames=YALI0F11121g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78080.1; -; Genomic_DNA.
DR   RefSeq; XP_505273.1; XM_505273.1.
DR   AlphaFoldDB; Q6C239; -.
DR   SMR; Q6C239; -.
DR   STRING; 4952.CAG78080; -.
DR   EnsemblFungi; CAG78080; CAG78080; YALI0_F11121g.
DR   GeneID; 2908179; -.
DR   KEGG; yli:YALI0F11121g; -.
DR   VEuPathDB; FungiDB:YALI0_F11121g; -.
DR   HOGENOM; CLU_046722_1_0_1; -.
DR   InParanoid; Q6C239; -.
DR   OMA; DYGHEKI; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   InterPro; IPR002014; VHS_dom.
DR   Pfam; PF08609; Fes1; 1.
DR   SMART; SM00185; ARM; 3.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..280
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285403"
FT   REPEAT          10..51
FT                   /note="ARM 1"
FT   REPEAT          70..109
FT                   /note="ARM 2"
FT   REPEAT          112..153
FT                   /note="ARM 3"
FT   REPEAT          156..196
FT                   /note="ARM 4"
FT   REPEAT          199..239
FT                   /note="ARM 5"
SQ   SEQUENCE   280 AA;  31249 MW;  860D72E4291F8B31 CRC64;
     MDKLLAWSVK QQQEGTNEPP PDPKLLAQLF GAPDDAQLMV QAMVVITQPD NKLEDKEVAF
     DNFEMLVENL DNANMMKNLK LWEPLLAQLS SPHPSLQKLA AWVVATATQN NPKSQEALVE
     QGDAGIKKLV DLTSHDDPEV VVKSLFALAS AIRNCDDAYK LFESADGLKK VVGHLKPDAT
     AQVKSKTLGV LTGILESETD LMKPEEKRQV FDILVKELET DDHIPSLERS LHVLVLLNQK
     GFPFTPEETE QVKKAAKRVE GKLDEEDVKY NEDLKYVNNL