FES_DICD3
ID FES_DICD3 Reviewed; 435 AA.
AC O51900; E0SLE0;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Iron(III) enterobactin esterase {ECO:0000250|UniProtKB:P13039};
DE EC=3.1.1.108 {ECO:0000250|UniProtKB:P13039};
DE AltName: Full=Enterochelin esterase;
DE AltName: Full=Ferric enterobactin esterase;
GN Name=fes; Synonyms=cbsH; OrderedLocusNames=Dda3937_03040;
OS Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Dickeya.
OX NCBI_TaxID=198628;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=3937;
RA Masclaux C., Rauscher L., Sauvage C., Expert D.;
RT "Enigmatic role of the E. chrysanthemi ferric enterobactin esterase encoded
RT from the fct-fes bidirectional promoter of the chrysobactin gene system.";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3937;
RX PubMed=21217001; DOI=10.1128/jb.01513-10;
RA Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA Blattner F.R., Keen N.T., Perna N.T.;
RT "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL J. Bacteriol. 193:2076-2077(2011).
CC -!- FUNCTION: Catalyzes the hydrolysis of ferric enterobactin (Fe-Ent). Is
CC responsible for the release of iron from ferric enterobactin.
CC {ECO:0000250|UniProtKB:P13039}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-
CC dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine;
CC Xref=Rhea:RHEA:30111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:28199, ChEBI:CHEBI:58154, ChEBI:CHEBI:143010;
CC EC=3.1.1.108; Evidence={ECO:0000250|UniProtKB:P13039};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30112;
CC Evidence={ECO:0000250|UniProtKB:P13039};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-
CC dihydroxybenzoyl)-L-serine]3 + H(+); Xref=Rhea:RHEA:59256,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28199,
CC ChEBI:CHEBI:143011; Evidence={ECO:0000250|UniProtKB:P13039};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59257;
CC Evidence={ECO:0000250|UniProtKB:P13039};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O =
CC Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-
CC dihydroxybenzoyl)-L-serine; Xref=Rhea:RHEA:59260, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58154, ChEBI:CHEBI:143011,
CC ChEBI:CHEBI:143012; Evidence={ECO:0000250|UniProtKB:P13039};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59261;
CC Evidence={ECO:0000250|UniProtKB:P13039};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O =
CC Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-
CC dihydroxybenzoyl)-L-serine; Xref=Rhea:RHEA:59264, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58154, ChEBI:CHEBI:143010,
CC ChEBI:CHEBI:143012; Evidence={ECO:0000250|UniProtKB:P13039};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59265;
CC Evidence={ECO:0000250|UniProtKB:P13039};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P13039}.
CC -!- SIMILARITY: Belongs to the Fes family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ADM99352.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF011334; AAB94505.1; -; Genomic_DNA.
DR EMBL; CP002038; ADM99352.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_033111969.1; NC_014500.1.
DR AlphaFoldDB; O51900; -.
DR SMR; O51900; -.
DR STRING; 198628.Dda3937_03040; -.
DR ESTHER; erwch-fes; A85-IroE-IroD-Fes-Yiel.
DR EnsemblBacteria; ADM99352; ADM99352; Dda3937_03040.
DR GeneID; 9734600; -.
DR KEGG; ddd:Dda3937_03040; -.
DR PATRIC; fig|198628.6.peg.3114; -.
DR eggNOG; COG2382; Bacteria.
DR HOGENOM; CLU_024314_3_0_6; -.
DR OMA; DRAGWRH; -.
DR OrthoDB; 1828423at2; -.
DR BioCyc; DDAD198628:DDA3937_RS14695-MON; -.
DR BRENDA; 3.1.1.108; 2141.
DR Proteomes; UP000006859; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008849; F:enterochelin esterase activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IMP:ASAP.
DR GO; GO:0042859; P:chrysobactin catabolic process; IMP:ASAP.
DR GO; GO:0006826; P:iron ion transport; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR021764; Enterochelin_esterase_N.
DR InterPro; IPR000801; Esterase-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR Pfam; PF11806; DUF3327; 1.
DR Pfam; PF00756; Esterase; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..435
FT /note="Iron(III) enterobactin esterase"
FT /id="PRO_0000087231"
FT CONFLICT 65..72
FT /note="VYADINGV -> CMPISTAW (in Ref. 1; AAB94505)"
FT /evidence="ECO:0000305"
FT CONFLICT 105
FT /note="S -> T (in Ref. 1; AAB94505)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="Missing (in Ref. 1; AAB94505)"
FT /evidence="ECO:0000305"
FT CONFLICT 149..150
FT /note="RD -> LY (in Ref. 1; AAB94505)"
FT /evidence="ECO:0000305"
FT CONFLICT 164..181
FT /note="AAPSQQAWRAVDNGTALP -> GGAVAAGLARGGQRYGVA (in Ref. 1;
FT AAB94505)"
FT /evidence="ECO:0000305"
FT CONFLICT 284..288
FT /note="QAARL -> HGRGS (in Ref. 1; AAB94505)"
FT /evidence="ECO:0000305"
FT CONFLICT 419
FT /note="G -> A (in Ref. 1; AAB94505)"
FT /evidence="ECO:0000305"
FT CONFLICT 422..423
FT /note="WL -> CV (in Ref. 1; AAB94505)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 435 AA; 48604 MW; CDCA55556188F961 CRC64;
MPAAQPSGFV ATLLSSPQAG EEAWWQQVAR LGTPLVEAQD SGRVRMTFLW RDPDGDERYS
AIRRVYADIN GVTDHHSTDP QSLERLPGTD VWHWSMAIEH DWRGSYSLIP IVAAQLPPVF
SDDGQLRDEQ QREWWCSLFP CAIADPLNRD QSWGEQLSAA HMPAAPSQQA WRAVDNGTAL
PPDAARLTVL DWKSEQLDNQ RRIWLYTTGI SDEPAQRPLC IVLDGQKWAE ETPLFAALEA
ETAAGHLPPA VWLFIDAIDG ETRCRELPCD AAFWLAVQDE LLPQAARLAP FSDDPDRTVV
SGQSYGGLAA LYAGLHWPQR FGRVLTQSGS FWWPNLQFIT DFDQRDTLEP GVLVTEVRQG
GQTAWPLVIF QEAGRREADI AFVNQQMHEA LVAAGHQVHQ RVYAGGHDTL CWRGGLIDGF
RWLLTGDDPQ AASRD
