FETB_ECOLI
ID FETB_ECOLI Reviewed; 259 AA.
AC P77307; Q2MBT6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Probable iron export permease protein FetB;
GN Name=fetB; Synonyms=ybbM; OrderedLocusNames=b0491, JW5066;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [5]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TOPOLOGY, DISRUPTION PHENOTYPE,
RP AND GENE NAME.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=24038693; DOI=10.1128/aem.02322-13;
RA Nicolaou S.A., Fast A.G., Nakamaru-Ogiso E., Papoutsakis E.T.;
RT "Overexpression of fetA (ybbL) and fetB (ybbM), encoding an iron exporter,
RT enhances resistance to oxidative stress in Escherichia coli.";
RL Appl. Environ. Microbiol. 79:7210-7219(2013).
CC -!- FUNCTION: Part of the ABC transporter complex FetAB, which is probably
CC involved in iron export and enhances resistance to H(2)O(2)-mediated
CC oxidative stress. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000269|PubMed:24038693}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FetA) and
CC two transmembrane proteins (FetB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:24038693}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:24038693}.
CC -!- DISRUPTION PHENOTYPE: Mutant exhibits increased sensitivity to H(2)O(2)
CC stress. {ECO:0000269|PubMed:24038693}.
CC -!- SIMILARITY: Belongs to the UPF0014 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB40245.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U82664; AAB40245.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC73593.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE76270.1; -; Genomic_DNA.
DR RefSeq; NP_415024.4; NC_000913.3.
DR RefSeq; WP_001295323.1; NZ_SSZK01000009.1.
DR AlphaFoldDB; P77307; -.
DR BioGRID; 4259852; 251.
DR STRING; 511145.b0491; -.
DR TCDB; 3.A.1.139.2; the atp-binding cassette (abc) superfamily.
DR jPOST; P77307; -.
DR PaxDb; P77307; -.
DR PRIDE; P77307; -.
DR EnsemblBacteria; AAC73593; AAC73593; b0491.
DR EnsemblBacteria; BAE76270; BAE76270; BAE76270.
DR GeneID; 67416425; -.
DR GeneID; 945137; -.
DR KEGG; ecj:JW5066; -.
DR KEGG; eco:b0491; -.
DR PATRIC; fig|511145.12.peg.512; -.
DR EchoBASE; EB3048; -.
DR eggNOG; COG0390; Bacteria.
DR HOGENOM; CLU_076147_1_0_6; -.
DR InParanoid; P77307; -.
DR OMA; PWYEPQY; -.
DR PhylomeDB; P77307; -.
DR BioCyc; EcoCyc:G6267-MON; -.
DR PRO; PR:P77307; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IMP:EcoCyc.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR005226; UPF0014_fam.
DR PANTHER; PTHR30028; PTHR30028; 1.
DR Pfam; PF03649; UPF0014; 1.
DR TIGRFAMs; TIGR00245; TIGR00245; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..259
FT /note="Probable iron export permease protein FetB"
FT /id="PRO_0000217858"
FT TOPO_DOM 1..5
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..91
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..117
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..218
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 259 AA; 28165 MW; 9AE9B134D1164E5D CRC64;
MNSHNITNES LALALMLVVV AILISHKEKL ALEKDILWSV GRAIIQLIIV GYVLKYIFSV
DDASLTLLMV LFICFNAAWN AQKRSKYIAK AFISSFIAIT VGAGITLAVL ILSGSIEFIP
MQVIPIAGMI AGNAMVAVGL CYNNLGQRVI SEQQQIQEKL SLGATPKQAS AILIRDSIRA
ALIPTVDSAK TVGLVSLPGM MSGLIFAGID PVKAIKYQIM VTFMLLSTAS LSTIIACYLT
YRKFYNSRHQ LVVTQLKKK
