ID   FETHP_PROFL             Reviewed;         324 AA.
AC   Q5KQS5;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=HSF-like protein;
DE            Short=HLP;
DE   Flags: Precursor;
OS   Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX   NCBI_TaxID=88087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Hori S., Aoki N., Deshimaru M., Terada S.;
RT   "HSF-like protein (HLP), a fetuin family protein without antihemorrhagic
RT   activity in Habu snake serum.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May not have antihemorrhagic activity.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver.
CC   -!- SIMILARITY: Belongs to the fetuin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00861}.
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DR   EMBL; AB200168; BAD88535.1; -; mRNA.
DR   AlphaFoldDB; Q5KQS5; -.
DR   SMR; Q5KQS5; -.
DR   MEROPS; I25.042; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR025760; Cystatin_Fetuin_A.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR001363; Prot_inh_fetuin_CS.
DR   Pfam; PF00031; Cystatin; 1.
DR   SMART; SM00043; CY; 2.
DR   SUPFAM; SSF54403; SSF54403; 2.
DR   PROSITE; PS51529; CYSTATIN_FETUIN_A; 2.
DR   PROSITE; PS01255; FETUIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..324
FT                   /note="HSF-like protein"
FT                   /id="PRO_5000052208"
FT   DOMAIN          21..130
FT                   /note="Cystatin fetuin-A-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
FT   DOMAIN          141..254
FT                   /note="Cystatin fetuin-A-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..315
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
FT   DISULFID        110..129
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
FT   DISULFID        143..146
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
FT   DISULFID        205..217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
FT   DISULFID        230..253
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00861"
SQ   SEQUENCE   324 AA;  36528 MW;  1FC7C3EEE39A9DE7 CRC64;
     MNSLVALVLL GQIIGSTVSF QLGPNMDCNT KGTKDWADIG VHYINEHKLH GYKQALNVIK
     IFRLLPSDGR SVIFHFNLNL LETECHVLDS TPVENCTVRP QHNHAVEMDC NVRIIHDITT
     FEDEVFVKCS STPGSVENIL RDCPKCPILL SPNDPHVVDS VEYVLNKHNE KLSGHIYEVL
     EISRGQHKYE PEAYYLEFVI VEINCTAQEA HDDYHQCHPY TAGEDHIAFC RSTVFRSHAS
     LEKPKDEKFE SDCVILDVKE GHAHSHLIEH HVGKYSTSPG YNSTDECVVE CPVAFVNKEV
     PTDISDHNTP PVKGCPGRVL HFQL