FETP_ECOLI
ID FETP_ECOLI Reviewed; 91 AA.
AC P0A8P3; P52065; Q2M9N1;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Probable Fe(2+)-trafficking protein;
GN Name=yggX; OrderedLocusNames=b2962, JW2929;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP PROTEIN SEQUENCE OF 2-13.
RC STRAIN=K12 / EMG2;
RX PubMed=9298646; DOI=10.1002/elps.1150180807;
RA Link A.J., Robison K., Church G.M.;
RT "Comparing the predicted and observed properties of proteins encoded in the
RT genome of Escherichia coli K-12.";
RL Electrophoresis 18:1259-1313(1997).
RN [4]
RP PROTEIN SEQUENCE OF 2-11.
RC STRAIN=K12;
RX PubMed=9868784; DOI=10.1111/j.1574-6968.1998.tb13343.x;
RA Wasinger V.C., Humphery-Smith I.;
RT "Small genes/gene-products in Escherichia coli K-12.";
RL FEMS Microbiol. Lett. 169:375-382(1998).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=B / BL21;
RX PubMed=10493123;
RX DOI=10.1002/(sici)1522-2683(19990801)20:11<2181::aid-elps2181>3.0.co;2-q;
RA Fountoulakis M., Takacs M.-F., Berndt P., Langen H., Takacs B.;
RT "Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite
RT chromatography.";
RL Electrophoresis 20:2181-2195(1999).
RN [6]
RP INDUCTION, AND FUNCTION.
RC STRAIN=K12 / GC4468;
RX PubMed=14594836; DOI=10.1128/jb.185.22.6624-6632.2003;
RA Pomposiello P.J., Koutsolioutsou A., Carrasco D., Demple B.;
RT "SoxRS-regulated expression and genetic analysis of the yggX gene of
RT Escherichia coli.";
RL J. Bacteriol. 185:6624-6632(2003).
RN [7]
RP STRUCTURE BY NMR, AND FUNCTION.
RX PubMed=15883188; DOI=10.1110/ps.051358105;
RA Osborne M.J., Siddiqui N., Landgraf D., Pomposiello P.J., Gehring K.;
RT "The solution structure of the oxidative stress-related protein YggX from
RT Escherichia coli.";
RL Protein Sci. 14:1673-1678(2005).
CC -!- FUNCTION: Could be a mediator in iron transactions between iron
CC acquisition and iron-requiring processes, such as synthesis and/or
CC repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain
CC high levels of aconitase under oxidative stress.
CC {ECO:0000269|PubMed:14594836, ECO:0000269|PubMed:15883188}.
CC -!- SUBUNIT: Monomer. {ECO:0000305}.
CC -!- INDUCTION: By oxidative stress and SoxS. {ECO:0000269|PubMed:14594836}.
CC -!- SIMILARITY: Belongs to the Fe(2+)-trafficking protein family.
CC {ECO:0000305}.
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DR EMBL; U28377; AAA69129.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75999.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77025.1; -; Genomic_DNA.
DR PIR; A65082; A65082.
DR RefSeq; NP_417437.1; NC_000913.3.
DR RefSeq; WP_000091700.1; NZ_STEB01000001.1.
DR PDB; 1YHD; NMR; -; A=2-91.
DR PDBsum; 1YHD; -.
DR AlphaFoldDB; P0A8P3; -.
DR SMR; P0A8P3; -.
DR BioGRID; 4262360; 66.
DR BioGRID; 851780; 1.
DR IntAct; P0A8P3; 3.
DR STRING; 511145.b2962; -.
DR SWISS-2DPAGE; P0A8P3; -.
DR jPOST; P0A8P3; -.
DR PaxDb; P0A8P3; -.
DR PRIDE; P0A8P3; -.
DR EnsemblBacteria; AAC75999; AAC75999; b2962.
DR EnsemblBacteria; BAE77025; BAE77025; BAE77025.
DR GeneID; 67415146; -.
DR GeneID; 947461; -.
DR KEGG; ecj:JW2929; -.
DR KEGG; eco:b2962; -.
DR PATRIC; fig|1411691.4.peg.3769; -.
DR EchoBASE; EB2809; -.
DR eggNOG; COG2924; Bacteria.
DR HOGENOM; CLU_170994_0_0_6; -.
DR InParanoid; P0A8P3; -.
DR OMA; SKQTMLI; -.
DR PhylomeDB; P0A8P3; -.
DR BioCyc; EcoCyc:G7532-MON; -.
DR EvolutionaryTrace; P0A8P3; -.
DR PRO; PR:P0A8P3; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0034599; P:cellular response to oxidative stress; IMP:EcoCyc.
DR Gene3D; 1.10.3880.10; -; 1.
DR HAMAP; MF_00686; Fe_traffic_YggX; 1.
DR InterPro; IPR007457; Fe_traffick_prot_YggX.
DR InterPro; IPR036766; Fe_traffick_prot_YggX_sf.
DR PANTHER; PTHR36965; PTHR36965; 1.
DR Pfam; PF04362; Iron_traffic; 1.
DR PIRSF; PIRSF029827; Fe_traffic_YggX; 1.
DR SUPFAM; SSF111148; SSF111148; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Iron; Reference proteome;
KW Stress response.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:9298646,
FT ECO:0000269|PubMed:9868784"
FT CHAIN 2..91
FT /note="Probable Fe(2+)-trafficking protein"
FT /id="PRO_0000214478"
FT STRAND 8..10
FT /evidence="ECO:0007829|PDB:1YHD"
FT STRAND 12..14
FT /evidence="ECO:0007829|PDB:1YHD"
FT HELIX 26..33
FT /evidence="ECO:0007829|PDB:1YHD"
FT HELIX 36..52
FT /evidence="ECO:0007829|PDB:1YHD"
FT HELIX 60..73
FT /evidence="ECO:0007829|PDB:1YHD"
FT TURN 74..78
FT /evidence="ECO:0007829|PDB:1YHD"
SQ SEQUENCE 91 AA; 10953 MW; 1E3625B77C32B94B CRC64;
MSRTIFCTFL QREAEGQDFQ LYPGELGKRI YNEISKEAWA QWQHKQTMLI NEKKLNMMNA
EHRKLLEQEM VNFLFEGKEV HIEGYTPEDK K
