ID   3MGH_MYCLB              Reviewed;         214 AA.
AC   B8ZRG8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
DE            EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
GN   OrderedLocusNames=MLBr01351;
OS   Mycobacterium leprae (strain Br4923).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=561304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Br4923;
RX   PubMed=19881526; DOI=10.1038/ng.477;
RA   Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A.,
RA   Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C.,
RA   Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H.,
RA   Vera-Cabrera L., Stefani M.M., Banu S., Macdonald M., Sapkota B.R.,
RA   Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A.,
RA   Rougemont J., Brennan P.J., Cole S.T.;
RT   "Comparative genomic and phylogeographic analysis of Mycobacterium
RT   leprae.";
RL   Nat. Genet. 41:1282-1289(2009).
CC   -!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00527}.
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DR   EMBL; FM211192; CAR71446.1; -; Genomic_DNA.
DR   RefSeq; WP_010908286.1; NC_011896.1.
DR   AlphaFoldDB; B8ZRG8; -.
DR   SMR; B8ZRG8; -.
DR   EnsemblBacteria; CAR71446; CAR71446; MLBr01351.
DR   KEGG; mlb:MLBr01351; -.
DR   HOGENOM; CLU_060471_3_1_11; -.
DR   OMA; VEAYHHT; -.
DR   OrthoDB; 1385409at2; -.
DR   Proteomes; UP000006900; Chromosome.
DR   GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd00540; AAG; 1.
DR   Gene3D; 3.10.300.10; -; 1.
DR   HAMAP; MF_00527; 3MGH; 1.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR003180; MPG.
DR   InterPro; IPR036995; MPG_sf.
DR   PANTHER; PTHR10429; PTHR10429; 1.
DR   Pfam; PF02245; Pur_DNA_glyco; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   TIGRFAMs; TIGR00567; 3mg; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase.
FT   CHAIN           1..214
FT                   /note="Putative 3-methyladenine DNA glycosylase"
FT                   /id="PRO_1000146270"
SQ   SEQUENCE   214 AA;  22313 MW;  6F97A6F363468528 CRC64;
     MRSPRRCKIC AVSADQLVVD PVVAAHRLLG ATITGRGVCA IVVEVEAYGG VPDGPWPDAA
     AHSYHGRNDR NAVMFGPPGR LYTYCSHGIH VCANVSCGPD GTAAAVLIRA GALENGADVA
     RSRRGASVRT VALARGPGNL CSALGITMDD NGIDVFAADS PVTLVLNEAQ EAMSGPRVGI
     SHAADRPWRL WLPGRPEVST YRRSPRAPAP GASD