ID   FEV_DANRE               Reviewed;         235 AA.
AC   A3FEM2;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Protein FEV;
DE   AltName: Full=Protein Pet-1;
GN   Name=fev; Synonyms=pet1; ORFNames=zgc:158720;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX   PubMed=17304529; DOI=10.1002/dvdy.21095;
RA   Lillesaar C., Tannhaeuser B., Stigloher C., Kremmer E., Bally-Cuif L.;
RT   "The serotonergic phenotype is acquired by converging genetic mechanisms
RT   within the zebrafish central nervous system.";
RL   Dev. Dyn. 236:1072-1084(2007).
CC   -!- FUNCTION: Functions as a transcriptional regulator. Functions in the
CC       differentiation and the maintenance of the central serotonergic
CC       neurons. May play a role in cell growth (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- TISSUE SPECIFICITY: Expressed by serotonergic neurons in anterior and
CC       posterior raphe. {ECO:0000269|PubMed:17304529}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in post-mitotic raphe serotonergic
CC       neurons. First detected at the 20 somites stage.
CC       {ECO:0000269|PubMed:17304529}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-14 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; EF370169; ABN42912.1; -; mRNA.
DR   RefSeq; NP_001315078.1; NM_001328149.1.
DR   RefSeq; XP_005167545.1; XM_005167488.3.
DR   AlphaFoldDB; A3FEM2; -.
DR   SMR; A3FEM2; -.
DR   STRING; 7955.ENSDARP00000087775; -.
DR   PaxDb; A3FEM2; -.
DR   Ensembl; ENSDART00000093343; ENSDARP00000087775; ENSDARG00000009242.
DR   GeneID; 791175; -.
DR   KEGG; dre:791175; -.
DR   CTD; 54738; -.
DR   ZFIN; ZDB-GENE-070112-1852; fev.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000161562; -.
DR   InParanoid; A3FEM2; -.
DR   OMA; TNMSCIA; -.
DR   OrthoDB; 1113327at2759; -.
DR   PhylomeDB; A3FEM2; -.
DR   TreeFam; TF316214; -.
DR   PRO; PR:A3FEM2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000009242; Expressed in intestine and 25 other tissues.
DR   ExpressionAtlas; A3FEM2; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:ZFIN.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0060218; P:hematopoietic stem cell differentiation; IMP:ZFIN.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:ZFIN.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..235
FT                   /note="Protein FEV"
FT                   /id="PRO_0000344207"
FT   DNA_BIND        58..138
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   235 AA;  26343 MW;  899D7F472FDF70BA CRC64;
     MKAYPFTSTT ATTMRQNCGG SLMFNMYLSD PTENLLKESK SPSWTPINTG VQKGSGQIQL
     WQFLLELLSD SANMTCIAWE GTNGEFKLID PDEVARRWGE RKSKPNMNYD KLSRALRYYY
     DKNIMTKVHG KRYAYKFDFN GLAQVCQPSS TEQAIYKFQS NFAPIQFSGI SKLNLVAPGV
     GPSGFSYWPG SPPTLYHSHN LQPPGPFGAV SASHLSCVNN INSLNNLNNI NNHYN