FEV_HUMAN
ID FEV_HUMAN Reviewed; 238 AA.
AC Q99581;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Protein FEV;
DE AltName: Full=Fifth Ewing variant protein;
DE AltName: Full=PC12 ETS domain-containing transcription factor 1;
DE Short=PC12 ETS factor 1;
DE Short=Pet-1;
GN Name=FEV; Synonyms=PET1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH EWSR1, AND
RP TISSUE SPECIFICITY.
RX PubMed=9121764; DOI=10.1038/sj.onc.1200933;
RA Peter M., Couturier J., Pacquement H., Michon J., Thomas G., Magdelenat H.,
RA Delattre O.;
RT "A new member of the ETS family fused to EWS in Ewing tumors.";
RL Oncogene 14:1159-1164(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12761502; DOI=10.1038/sj.onc.1206572;
RA Maurer P., T'Sas F., Coutte L., Callens N., Brenner C., Van Lint C.,
RA de Launoit Y., Baert J.-L.;
RT "FEV acts as a transcriptional repressor through its DNA-binding ETS domain
RT and alanine-rich domain.";
RL Oncogene 22:3319-3329(2003).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=15003288; DOI=10.1016/j.neulet.2003.12.086;
RA Maurer P., Rorive S., de Kerchove d'Exaerde A., Schiffmann S.N., Salmon I.,
RA de Launoit Y.;
RT "The Ets transcription factor Fev is specifically expressed in the human
RT central serotonergic neurons.";
RL Neurosci. Lett. 357:215-218(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=15986391; DOI=10.1002/syn.20178;
RA Iyo A.H., Porter B., Deneris E.S., Austin M.C.;
RT "Regional distribution and cellular localization of the ETS-domain
RT transcription factor, FEV, mRNA in the human postmortem brain.";
RL Synapse 57:223-228(2005).
RN [8]
RP CHARACTERIZATION OF THE EWSR1-FEV FUSION PROTEIN.
RX PubMed=17172842; DOI=10.4161/cc.5.23.3505;
RA Braunreiter C.L., Hancock J.D., Coffin C.M., Boucher K.M., Lessnick S.L.;
RT "Expression of EWS-ETS fusions in NIH3T3 cells reveals significant
RT differences to Ewing's sarcoma.";
RL Cell Cycle 5:2753-2759(2006).
RN [9]
RP INVOLVEMENT IN SIDS.
RX PubMed=17597646; DOI=10.1203/pdr.0b013e3180a725a0;
RA Rand C.M., Berry-Kravis E.M., Zhou L., Fan W., Weese-Mayer D.E.;
RT "Sudden infant death syndrome: rare mutation in the serotonin system FEV
RT gene.";
RL Pediatr. Res. 62:180-182(2007).
CC -!- FUNCTION: Functions as a transcriptional regulator. According to
CC PubMed:12761502, it functions as a transcriptional repressor. Functions
CC in the differentiation and the maintenance of the central serotonergic
CC neurons. May play a role in cell growth. {ECO:0000269|PubMed:12761502}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237,
CC ECO:0000269|PubMed:12761502}.
CC -!- TISSUE SPECIFICITY: In brain, exclusively expressed in the major
CC serotonergic neurons of the dorsal and median raphe nuclei located in
CC the midbrain and pons. Also detected in prostate and small intestine.
CC {ECO:0000269|PubMed:15003288, ECO:0000269|PubMed:15986391,
CC ECO:0000269|PubMed:9121764}.
CC -!- DISEASE: Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the
CC sudden death of an infant younger than 1 year that remains unexplained
CC after a thorough case investigation, including performance of a
CC complete autopsy, examination of the death scene, and review of
CC clinical history. Pathophysiologic mechanisms for SIDS may include
CC respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory
CC instability, and inborn errors of metabolism, but definitive pathogenic
CC mechanisms precipitating an infant sudden death remain elusive.
CC {ECO:0000269|PubMed:17597646}. Note=Disease susceptibility may be
CC associated with variants affecting the gene represented in this entry.
CC -!- DISEASE: Note=A chromosomal aberration involving FEV is found in Ewing
CC tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV
CC fusion protein with a potential oncogenic activity.
CC {ECO:0000269|PubMed:9121764}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; Y08976; CAA70169.1; -; mRNA.
DR EMBL; AC097468; AAX88917.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70664.1; -; Genomic_DNA.
DR EMBL; BC023511; AAH23511.1; -; mRNA.
DR CCDS; CCDS2428.1; -.
DR RefSeq; NP_059991.1; NM_017521.2.
DR PDB; 2YPR; X-ray; 2.64 A; A/B=42-141.
DR PDB; 3ZP5; X-ray; 2.00 A; A=42-141.
DR PDBsum; 2YPR; -.
DR PDBsum; 3ZP5; -.
DR AlphaFoldDB; Q99581; -.
DR SMR; Q99581; -.
DR BioGRID; 120120; 202.
DR IntAct; Q99581; 201.
DR STRING; 9606.ENSP00000295727; -.
DR iPTMnet; Q99581; -.
DR PhosphoSitePlus; Q99581; -.
DR BioMuta; FEV; -.
DR DMDM; 74762701; -.
DR MassIVE; Q99581; -.
DR PaxDb; Q99581; -.
DR PeptideAtlas; Q99581; -.
DR PRIDE; Q99581; -.
DR ProteomicsDB; 78340; -.
DR Antibodypedia; 34294; 122 antibodies from 24 providers.
DR DNASU; 54738; -.
DR Ensembl; ENST00000295727.2; ENSP00000295727.1; ENSG00000163497.3.
DR GeneID; 54738; -.
DR KEGG; hsa:54738; -.
DR MANE-Select; ENST00000295727.2; ENSP00000295727.1; NM_017521.3; NP_059991.1.
DR UCSC; uc002vji.1; human.
DR CTD; 54738; -.
DR DisGeNET; 54738; -.
DR GeneCards; FEV; -.
DR HGNC; HGNC:18562; FEV.
DR HPA; ENSG00000163497; Tissue enriched (brain).
DR MIM; 272120; phenotype.
DR MIM; 607150; gene.
DR neXtProt; NX_Q99581; -.
DR OpenTargets; ENSG00000163497; -.
DR PharmGKB; PA134875093; -.
DR VEuPathDB; HostDB:ENSG00000163497; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000161562; -.
DR HOGENOM; CLU_045216_4_0_1; -.
DR InParanoid; Q99581; -.
DR OMA; TNMSCIA; -.
DR OrthoDB; 1113327at2759; -.
DR PhylomeDB; Q99581; -.
DR TreeFam; TF316214; -.
DR PathwayCommons; Q99581; -.
DR SignaLink; Q99581; -.
DR SIGNOR; Q99581; -.
DR BioGRID-ORCS; 54738; 18 hits in 1091 CRISPR screens.
DR GenomeRNAi; 54738; -.
DR Pharos; Q99581; Tbio.
DR PRO; PR:Q99581; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q99581; protein.
DR Bgee; ENSG00000163497; Expressed in islet of Langerhans and 71 other tissues.
DR Genevisible; Q99581; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048665; P:neuron fate specification; IEA:Ensembl.
DR GO; GO:0042551; P:neuron maturation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosomal rearrangement; Developmental protein;
KW Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..238
FT /note="Protein FEV"
FT /id="PRO_0000344204"
FT DNA_BIND 47..127
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 129..238
FT /note="May mediate active transcriptional repression"
FT SITE 18..19
FT /note="Breakpoint for insertion to form EWS-FEV fusion
FT protein"
FT HELIX 49..57
FT /evidence="ECO:0007829|PDB:3ZP5"
FT HELIX 60..62
FT /evidence="ECO:0007829|PDB:3ZP5"
FT TURN 63..65
FT /evidence="ECO:0007829|PDB:3ZP5"
FT STRAND 67..71
FT /evidence="ECO:0007829|PDB:3ZP5"
FT STRAND 74..76
FT /evidence="ECO:0007829|PDB:3ZP5"
FT HELIX 80..91
FT /evidence="ECO:0007829|PDB:3ZP5"
FT HELIX 98..107
FT /evidence="ECO:0007829|PDB:3ZP5"
FT TURN 108..112
FT /evidence="ECO:0007829|PDB:3ZP5"
FT STRAND 113..116
FT /evidence="ECO:0007829|PDB:3ZP5"
FT STRAND 123..126
FT /evidence="ECO:0007829|PDB:3ZP5"
FT HELIX 128..134
FT /evidence="ECO:0007829|PDB:3ZP5"
SQ SEQUENCE 238 AA; 25030 MW; 057E4A76FBDD6E0A CRC64;
MRQSGASQPL LINMYLPDPV GDGLFKDGKN PSWGPLSPAV QKGSGQIQLW QFLLELLADR
ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMSKVHGK
RYAYRFDFQG LAQACQPPPA HAHAAAAAAA AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL
MAASAGVAPA GFSYWPGPGP AATAAAATAA LYPSPSLQPP PGPFGAVAAA SHLGGHYH
