FEV_MOUSE
ID FEV_MOUSE Reviewed; 237 AA.
AC Q8QZW2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Protein FEV;
DE AltName: Full=PC12 ETS domain-containing transcription factor 1;
DE Short=PC12 ETS factor 1;
DE Short=Pet-1;
DE Short=mPet-1;
GN Name=Fev; Synonyms=Pet1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=129/SvJ, and C3H/HeJ; TISSUE=Fetal brain;
RX PubMed=11875656; DOI=10.1007/s00427-001-0208-x;
RA Pfaar H., von Holst A., Vogt Weisenhorn D.M., Brodski C., Guimera J.,
RA Wurst W.;
RT "mPet-1, a mouse ETS-domain transcription factor, is expressed in central
RT serotonergic neurons.";
RL Dev. Genes Evol. 212:43-46(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=14602809; DOI=10.1523/jneurosci.23-31-09961.2003;
RA Cheng L., Chen C.-L., Luo P., Tan M., Qiu M., Johnson R., Ma Q.;
RT "Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic
RT neurotransmitter phenotype.";
RL J. Neurosci. 23:9961-9967(2003).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12546819; DOI=10.1016/s0896-6273(02)01167-4;
RA Hendricks T.J., Fyodorov D.V., Wegman L.J., Lelutiu N.B., Pehek E.A.,
RA Yamamoto B., Silver J., Weeber E.J., Sweatt J.D., Deneris E.S.;
RT "Pet-1 ETS gene plays a critical role in 5-HT neuron development and is
RT required for normal anxiety-like and aggressive behavior.";
RL Neuron 37:233-247(2003).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17656160; DOI=10.1016/j.resp.2007.06.002;
RA Erickson J.T., Shafer G., Rossetti M.D., Wilson C.G., Deneris E.S.;
RT "Arrest of 5HT neuron differentiation delays respiratory maturation and
RT impairs neonatal homeostatic responses to environmental challenges.";
RL Respir. Physiol. Neurobiol. 159:85-101(2007).
CC -!- FUNCTION: Functions as a transcriptional regulator. May function as a
CC transcriptional repressor. Functions in the differentiation and the
CC maintenance of the central serotonergic neurons. May play a role in
CC cell growth. {ECO:0000269|PubMed:12546819, ECO:0000269|PubMed:14602809,
CC ECO:0000269|PubMed:17656160}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237,
CC ECO:0000269|PubMed:11875656}.
CC -!- TISSUE SPECIFICITY: Expressed in central serotonergic neurons.
CC {ECO:0000269|PubMed:11875656}.
CC -!- DEVELOPMENTAL STAGE: First expressed at 11 dpc in the rostral cluster
CC of serotonergic neurons. During development, expression is restricted
CC to serotonergic neurons located in the raphe nuclei.
CC {ECO:0000269|PubMed:11875656, ECO:0000269|PubMed:14602809}.
CC -!- DISRUPTION PHENOTYPE: Mice display heightened aggressive and anxiety-
CC like behaviors. They also display an extended and exacerbated period of
CC breathing instability immediately after birth which results in an
CC increased risk of death. This is associated with loss of the
CC differentiation of a large number of the serotonin (5-HT) neurons
CC without major structural abnormalities of the brain.
CC {ECO:0000269|PubMed:12546819, ECO:0000269|PubMed:17656160}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; AY049085; AAL13055.1; -; mRNA.
DR EMBL; AY049086; AAL13056.1; -; Genomic_DNA.
DR EMBL; CH466548; EDL00354.1; -; Genomic_DNA.
DR EMBL; BC138435; AAI38436.1; -; mRNA.
DR EMBL; BC138436; AAI38437.1; -; mRNA.
DR CCDS; CCDS15058.1; -.
DR RefSeq; NP_694751.1; NM_153111.2.
DR AlphaFoldDB; Q8QZW2; -.
DR SMR; Q8QZW2; -.
DR STRING; 10090.ENSMUSP00000070878; -.
DR PhosphoSitePlus; Q8QZW2; -.
DR MaxQB; Q8QZW2; -.
DR PaxDb; Q8QZW2; -.
DR PRIDE; Q8QZW2; -.
DR Antibodypedia; 34294; 122 antibodies from 24 providers.
DR DNASU; 260298; -.
DR Ensembl; ENSMUST00000068631; ENSMUSP00000070878; ENSMUSG00000055197.
DR GeneID; 260298; -.
DR KEGG; mmu:260298; -.
DR UCSC; uc007bnh.2; mouse.
DR CTD; 54738; -.
DR MGI; MGI:2449712; Fev.
DR VEuPathDB; HostDB:ENSMUSG00000055197; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000161562; -.
DR HOGENOM; CLU_045216_4_0_1; -.
DR InParanoid; Q8QZW2; -.
DR OMA; TNMSCIA; -.
DR OrthoDB; 1113327at2759; -.
DR PhylomeDB; Q8QZW2; -.
DR TreeFam; TF316214; -.
DR BioGRID-ORCS; 260298; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8QZW2; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8QZW2; protein.
DR Bgee; ENSMUSG00000055197; Expressed in central gray substance of midbrain and 42 other tissues.
DR ExpressionAtlas; Q8QZW2; baseline and differential.
DR Genevisible; Q8QZW2; MM.
DR GO; GO:0043025; C:neuronal cell body; TAS:ParkinsonsUK-UCL.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048665; P:neuron fate specification; IMP:MGI.
DR GO; GO:0042551; P:neuron maturation; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:1905627; P:regulation of serotonin biosynthetic process; NAS:ParkinsonsUK-UCL.
DR GO; GO:0051611; P:regulation of serotonin uptake; NAS:ParkinsonsUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..237
FT /note="Protein FEV"
FT /id="PRO_0000344205"
FT DNA_BIND 47..127
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 129..237
FT /note="May mediate active transcriptional repression"
FT /evidence="ECO:0000250"
SQ SEQUENCE 237 AA; 24991 MW; E82F76640038BA3A CRC64;
MRQSGTSQPL LINMYLPDPV GDGLFKEGKS PSWGPLSPAV QKGSGQIQLW QFLLELLADR
ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMSKVHGK
RYAYRFDFQG LAQACQPPPA HAHAAAAAAA AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL
MAASAGVAPA GFSYWPGPNA TAAAAATAAL YPTPGLQPPP GPFGAVAAAS HLGGHYH
