FEV_RAT
ID FEV_RAT Reviewed; 237 AA.
AC O70132;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein FEV;
DE AltName: Full=PC12 ETS domain-containing transcription factor 1;
DE Short=PC12 ETS factor 1;
DE Short=Pet-1;
GN Name=Fev; Synonyms=Pet1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Pheochromocytoma;
RX PubMed=9468386;
RX DOI=10.1002/(sici)1097-4695(19980205)34:2<151::aid-neu5>3.0.co;2-1;
RA Fyodorov D., Nelson T., Deneris E.;
RT "Pet-1, a novel ETS domain factor that can activate neuronal nAchR gene
RT transcription.";
RL J. Neurobiol. 34:151-163(1998).
RN [2]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=10575032; DOI=10.1523/jneurosci.19-23-10348.1999;
RA Hendricks T., Francis N., Fyodorov D., Deneris E.S.;
RT "The ETS domain factor Pet-1 is an early and precise marker of central
RT serotonin neurons and interacts with a conserved element in serotonergic
RT genes.";
RL J. Neurosci. 19:10348-10356(1999).
CC -!- FUNCTION: Functions as a transcriptional regulator. May function as a
CC transcriptional repressor. Functions in the differentiation and the
CC maintenance of the central serotonergic neurons. May play a role in
CC cell growth. {ECO:0000269|PubMed:10575032, ECO:0000269|PubMed:9468386}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in central serotonergic
CC neurons. Also expressed in adrenal gland and to a lower extent in small
CC intestine and eye. {ECO:0000269|PubMed:10575032,
CC ECO:0000269|PubMed:9468386}.
CC -!- DEVELOPMENTAL STAGE: Earliest expression is detected at E12.5 in the
CC developing brain in regions corresponding to the future rostral and
CC caudal serotonergic neuron clusters. {ECO:0000269|PubMed:10575032}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC12859.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; U91679; AAC12859.1; ALT_SEQ; mRNA.
DR RefSeq; NP_653354.2; NM_144753.2.
DR AlphaFoldDB; O70132; -.
DR SMR; O70132; -.
DR STRING; 10116.ENSRNOP00000024190; -.
DR PhosphoSitePlus; O70132; -.
DR PaxDb; O70132; -.
DR Ensembl; ENSRNOT00000024190; ENSRNOP00000024190; ENSRNOG00000017856.
DR GeneID; 246271; -.
DR KEGG; rno:246271; -.
DR UCSC; RGD:628860; rat.
DR CTD; 54738; -.
DR RGD; 628860; Fev.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000161562; -.
DR HOGENOM; CLU_045216_4_0_1; -.
DR InParanoid; O70132; -.
DR OrthoDB; 1113327at2759; -.
DR PhylomeDB; O70132; -.
DR TreeFam; TF316214; -.
DR PRO; PR:O70132; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Genevisible; O70132; RN.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048665; P:neuron fate specification; ISO:RGD.
DR GO; GO:0042551; P:neuron maturation; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..237
FT /note="Protein FEV"
FT /id="PRO_0000344206"
FT DNA_BIND 47..127
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 129..237
FT /note="May mediate active transcriptional repression"
FT /evidence="ECO:0000250"
SQ SEQUENCE 237 AA; 24991 MW; E82F76640038BA3A CRC64;
MRQSGTSQPL LINMYLPDPV GDGLFKEGKS PSWGPLSPAV QKGSGQIQLW QFLLELLADR
ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMSKVHGK
RYAYRFDFQG LAQACQPPPA HAHAAAAAAA AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL
MAASAGVAPA GFSYWPGPNA TAAAAATAAL YPTPGLQPPP GPFGAVAAAS HLGGHYH
