FEX1_CANAL
ID FEX1_CANAL Reviewed; 390 AA.
AC Q5AFH3; A0A1D8PQJ4; G1U9W9; Q3MPV2;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Fluoride export protein 1 {ECO:0000303|PubMed:24173035};
GN Name=FEX1 {ECO:0000303|PubMed:24173035};
GN OrderedLocusNames=CAALFM_C700270WA; ORFNames=CaO19.7095, orf19.7095;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA Mikami Y.;
RT "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT syntenic analysis against the Saccharomyces cerevisiae genome.";
RL Genetics 170:1525-1537(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24173035; DOI=10.1073/pnas.1310439110;
RA Li S., Smith K.D., Davis J.H., Gordon P.B., Breaker R.R., Strobel S.A.;
RT "Eukaryotic resistance to fluoride toxicity mediated by a widespread family
RT of fluoride export proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19018-19023(2013).
CC -!- FUNCTION: Fluoride channel required for the rapid expulsion of
CC cytoplasmic fluoride. {ECO:0000269|PubMed:24173035}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q08913};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Highly sensible to fluoride. Growth is inhibited
CC at more than a 300-fold lower fluoride concentration than in the wild-
CC type. Has increased intracellular fluoride concentrations.
CC {ECO:0000269|PubMed:24173035}.
CC -!- SIMILARITY: Belongs to the fluoride exporter Fluc/FEX family.
CC {ECO:0000305}.
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DR EMBL; AP006852; BAE44558.1; -; Genomic_DNA.
DR EMBL; CP017629; AOW30406.1; -; Genomic_DNA.
DR RefSeq; XP_720386.1; XM_715293.1.
DR AlphaFoldDB; Q5AFH3; -.
DR STRING; 237561.Q5AFH3; -.
DR PRIDE; Q5AFH3; -.
DR EnsemblFungi; KHC71723; KHC71723; W5Q_05082.
DR EnsemblFungi; KHC80844; KHC80844; I503_05038.
DR GeneID; 3637977; -.
DR KEGG; cal:CAALFM_C700270WA; -.
DR CGD; CAL0000174776; orf19.7095.
DR VEuPathDB; FungiDB:C7_00270W_A; -.
DR eggNOG; ENOG502RZ3R; Eukaryota.
DR HOGENOM; CLU_030507_1_2_1; -.
DR InParanoid; Q5AFH3; -.
DR OMA; RSWTFSM; -.
DR OrthoDB; 848812at2759; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 2.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..390
FT /note="Fluoride export protein 1"
FT /id="PRO_0000437221"
FT TOPO_DOM 1..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..100
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..185
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..256
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 257..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..290
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..338
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 42820 MW; 9662ECCDD0363F13 CRC64;
MVAPLVSESQ SSSIEETDEQ QQQYQQLARR RTIQSDLVDI EAESISSALP EGFNYEKKTT
ATRFLDKTQK YYPVILNIVH GAIWGVLVRK GLMSLTTYSG SFLSGVIWAN FAACVVMGLA
IDGEVFWIRL LEEKDYPNKG AIPVYTGLTT GFCGTVSSFS SVILEAFNKA ADTDIGVRHH
YPNGAYGIMQ FLAVILAQFG LSIMGFHMGK QFSAVVDNYL PLVTKRIYKV LELTSMILGV
VLVVITCILI GVKKQGSWRS WTFSMLFAPF GALLRYYLSK FLNNKVSNFP LGTFTANFLG
TLLLAVFTLL ARGKLPGGKG HIVTNTIALH VLEGLDDGFC GGLTTVSTFV VELFGLKTLF
SYRYGTISIL VCFAGVVLIL GSYNWSVGLD
