FEX1_SCHPO
ID FEX1_SCHPO Reviewed; 311 AA.
AC P0CU19; Q9UTS8;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 1.
DT 25-MAY-2022, entry version 26.
DE RecName: Full=Fluoride export protein 1 {ECO:0000250|UniProtKB:Q08913};
GN Name=fex1; ORFNames=SPAC977.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10712506; DOI=10.1091/mbc.11.3.873;
RA Albrecht E.B., Hunyady A.B., Stark G.R., Patterson T.E.;
RT "Mechanisms of sod2 gene amplification in Schizosaccharomyces pombe.";
RL Mol. Biol. Cell 11:873-886(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Fluoride channel required for the rapid expulsion of
CC cytoplasmic fluoride. {ECO:0000250|UniProtKB:Q08913}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q08913};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the fluoride exporter Fluc/FEX family.
CC {ECO:0000305}.
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DR EMBL; AF192974; AAF13925.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB69633.1; -; Genomic_DNA.
DR PIR; T50283; T50283.
DR RefSeq; NP_001018767.1; NM_001020942.2.
DR RefSeq; NP_592783.1; NM_001018183.2.
DR AlphaFoldDB; P0CU19; -.
DR SMR; P0CU19; -.
DR STRING; 4896.SPAC977.11.1; -.
DR EnsemblFungi; SPAC977.11.1; SPAC977.11.1:pep; SPAC977.11.
DR EnsemblFungi; SPBPB8B6.06c.1; SPBPB8B6.06c.1:pep; SPBPB8B6.06c.
DR GeneID; 2543234; -.
DR GeneID; 3361186; -.
DR KEGG; spo:SPAC977.11; -.
DR KEGG; spo:SPBPB8B6.06c; -.
DR PomBase; SPAC977.11; fex1.
DR VEuPathDB; FungiDB:SPAC977.11; -.
DR VEuPathDB; FungiDB:SPBPB8B6.06c; -.
DR eggNOG; ENOG502QT5F; Eukaryota.
DR OMA; RSWTFSM; -.
DR PhylomeDB; P0CU19; -.
DR PRO; PR:P0CU19; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0140114; P:cellular detoxification of fluoride; IMP:PomBase.
DR GO; GO:0140116; P:fluoride export across plasma membrane; IMP:PomBase.
DR GO; GO:1903424; P:fluoride transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003691; CrcB.
DR PANTHER; PTHR28259; PTHR28259; 1.
DR Pfam; PF02537; CRCB; 2.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..311
FT /note="Fluoride export protein 1"
FT /id="PRO_0000317096"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..29
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..106
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..186
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..250
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 251..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..311
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q08913"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 311 AA; 34557 MW; D86BBC7F953C1338 CRC64;
MLLTQSYFCI MSMLGTLARL GLTALNTYPG APFSGLLWVQ FVGCVIMGFC QTESVFFPRP
KHNATFLLAI TTGFCGSLTT FSSWMLQMFT GMANLDPFER RGRGYSFLSV VSDFMVTMCI
AMSSLIWGKQ IGKTTGQWRI GKVAFAWPIP AHTHIVVRVL LLLLSICFFV GAAFYTAYTT
NVTHRGIGFS LIFSPFAALT RLYLARFLNS PQYFIPYGTL CANVFATLLL SIMYMIPQIT
HCTPVSRSVM YGIQNGFCAV LSTLSTFSNE LHTMPIKRAY IYCIISVAIS FSICVIVDGA
TAWGHGYTEK Y
