ID   FEZ2_MOUSE              Reviewed;         348 AA.
AC   Q6TYB5;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Fasciculation and elongation protein zeta-2;
DE   AltName: Full=Zygin II;
DE   AltName: Full=Zygin-2;
GN   Name=Fez2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CD-1; TISSUE=Testis;
RA   Lopez-Casas P.P., Del Mazo J.;
RT   "Fez2 expression in mouse testis.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in axonal outgrowth and fasciculation.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. May form heterodimers with FEZ1.
CC       Interacts with synaptotagmin (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the zygin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY382580; AAR36860.1; -; mRNA.
DR   EMBL; BC096619; AAH96619.1; -; mRNA.
DR   CCDS; CCDS28977.1; -.
DR   RefSeq; NP_955519.1; NM_199448.3.
DR   AlphaFoldDB; Q6TYB5; -.
DR   SMR; Q6TYB5; -.
DR   BioGRID; 230350; 27.
DR   IntAct; Q6TYB5; 1.
DR   STRING; 10090.ENSMUSP00000068987; -.
DR   iPTMnet; Q6TYB5; -.
DR   PhosphoSitePlus; Q6TYB5; -.
DR   EPD; Q6TYB5; -.
DR   jPOST; Q6TYB5; -.
DR   MaxQB; Q6TYB5; -.
DR   PaxDb; Q6TYB5; -.
DR   PRIDE; Q6TYB5; -.
DR   ProteomicsDB; 272993; -.
DR   Antibodypedia; 29294; 175 antibodies from 26 providers.
DR   DNASU; 225020; -.
DR   Ensembl; ENSMUST00000070039; ENSMUSP00000068987; ENSMUSG00000056121.
DR   GeneID; 225020; -.
DR   KEGG; mmu:225020; -.
DR   UCSC; uc008dov.2; mouse.
DR   CTD; 9637; -.
DR   MGI; MGI:2675856; Fez2.
DR   VEuPathDB; HostDB:ENSMUSG00000056121; -.
DR   eggNOG; KOG3919; Eukaryota.
DR   GeneTree; ENSGT00390000017627; -.
DR   InParanoid; Q6TYB5; -.
DR   TreeFam; TF313128; -.
DR   BioGRID-ORCS; 225020; 0 hits in 71 CRISPR screens.
DR   PRO; PR:Q6TYB5; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q6TYB5; protein.
DR   Bgee; ENSMUSG00000056121; Expressed in epithelium of lens and 258 other tissues.
DR   ExpressionAtlas; Q6TYB5; baseline and differential.
DR   Genevisible; Q6TYB5; MM.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:GO_Central.
DR   InterPro; IPR011680; FEZ.
DR   InterPro; IPR015641; FEZ_2.
DR   PANTHER; PTHR12394; PTHR12394; 2.
DR   PANTHER; PTHR12394:SF11; PTHR12394:SF11; 2.
DR   Pfam; PF07763; FEZ; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Disulfide bond; Phosphoprotein; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Fasciculation and elongation protein zeta-2"
FT                   /id="PRO_0000189529"
FT   REGION          11..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          206..280
FT                   /evidence="ECO:0000255"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHY8"
FT   MOD_RES         171
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHY8"
FT   MOD_RES         190
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHY8"
FT   DISULFID        148
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   348 AA;  39101 MW;  031D68EF532BB781 CRC64;
     MAADGDWQDF YEFQEPAGSV QEQENCNASP EAGAGAHAGG DSFPALASSL EEKLSLCFRP
     TSEAEPPRAA VRPITECSLL QGDEIWNALT DNYGNVMPVD WKSSHTRTLH LLTLNLSEKG
     MNDGLLFDAS DEEELREQLD MHSIIVSCVN EEPLFTADQV IEEIEEMMQE SPDPEDDETP
     TQSDRLSMLS QEIQTLKRSS MSSYEERVKR LSVSELNELL EEIEAAIKQY SEELVQQLAL
     RDELEFEKEV ENSFISALIE VQNKQKEHKE TAKKKKKLKS GSSQNGRSER SHMPGTYLTT
     VIPYEKKSGP PSVEDLQILT KILHAMKEDS EKVPSLLTDY ILKVLCPT