ID   FEZ2_RAT                Reviewed;         375 AA.
AC   P97578; Q76LN1; Q9JJ35; Q9JJ36;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Fasciculation and elongation protein zeta-2;
DE   AltName: Full=Zygin II;
DE   AltName: Full=Zygin-2;
DE   AltName: Full=Zygin-related protein types I/II;
GN   Name=Fez2; Synonyms=Zrp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=14697253; DOI=10.1016/j.bbrc.2003.12.006;
RA   Fujita T., Ikuta J., Hamada J., Okajima T., Tatematsu K., Tanizawa K.,
RA   Kuroda S.;
RT   "Identification of a tissue-non-specific homologue of axonal fasciculation
RT   and elongation protein zeta-1.";
RL   Biochem. Biophys. Res. Commun. 313:738-744(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 52-375 (ISOFORM 1).
RA   Sugita S., von Poser C., Rosahl T.W., Hata Y., Suedhof T.C.;
RT   "Zigins: a family of synaptotagmin-interacting proteins related to unc-
RT   76.";
RL   Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 297-375 (ISOFORMS 1 AND 2).
RC   STRAIN=Fischer; TISSUE=Fibroblast;
RA   Zhang Q.Y., Blair D.G.;
RT   "Effective generation of viral/cell fusion transcripts by poly-A signal
RT   sequence mutant retroviruses: evidence for increased tumorigenicity by
RT   infected rat fibroblasts.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in axonal outgrowth and fasciculation.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. May form heterodimers with FEZ1.
CC       Interacts with synaptotagmin (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Zrp1;
CC         IsoId=P97578-1; Sequence=Displayed;
CC       Name=2; Synonyms=Zrp2;
CC         IsoId=P97578-2; Sequence=VSP_015758;
CC   -!- SIMILARITY: Belongs to the zygin family. {ECO:0000305}.
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DR   EMBL; AB076183; BAD06452.1; -; mRNA.
DR   EMBL; U64689; AAB40631.1; -; mRNA.
DR   EMBL; AF120109; AAF87266.1; -; mRNA.
DR   EMBL; AF120110; AAF87267.1; -; mRNA.
DR   RefSeq; NP_446052.2; NM_053600.2.
DR   AlphaFoldDB; P97578; -.
DR   SMR; P97578; -.
DR   STRING; 10116.ENSRNOP00000049923; -.
DR   PhosphoSitePlus; P97578; -.
DR   GeneID; 94269; -.
DR   KEGG; rno:94269; -.
DR   UCSC; RGD:619709; rat. [P97578-1]
DR   CTD; 9637; -.
DR   RGD; 619709; Fez2.
DR   eggNOG; KOG3919; Eukaryota.
DR   InParanoid; P97578; -.
DR   OrthoDB; 1186463at2759; -.
DR   PhylomeDB; P97578; -.
DR   PRO; PR:P97578; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:GO_Central.
DR   GO; GO:0017157; P:regulation of exocytosis; TAS:RGD.
DR   InterPro; IPR011680; FEZ.
DR   InterPro; IPR015641; FEZ_2.
DR   PANTHER; PTHR12394; PTHR12394; 1.
DR   PANTHER; PTHR12394:SF11; PTHR12394:SF11; 1.
DR   Pfam; PF07763; FEZ; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Disulfide bond; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..375
FT                   /note="Fasciculation and elongation protein zeta-2"
FT                   /id="PRO_0000189530"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          156..177
FT                   /evidence="ECO:0000255"
FT   COILED          206..281
FT                   /evidence="ECO:0000255"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHY8"
FT   MOD_RES         171
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHY8"
FT   MOD_RES         190
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHY8"
FT   DISULFID        148
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         297..323
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_015758"
SQ   SEQUENCE   375 AA;  42086 MW;  D7BA3EE635D6D982 CRC64;
     MAADGDWQDF YEFQEPAGSV RDQENCNASP EAGAGAHAGG DSFPALASSL EEKLSLCFRP
     TSDADPPRAA VRPITERSLL QGDEIWNALT DNYGNVMPVD WKSSHTRTLH LLTLNLTEKG
     MSDGLPFDTS DEEELREQLD MHSIIVSCVN EEPLFTADQV IEEIEEMMQE SPDLEDDETP
     TQSDRLSMLS QEIQTLKSSS MSSCEERVKR LSVSELNELL EEIETAIKEY SEELVQQLAL
     RDELEFEKEV ENSFISALIE VQNKQKEHKE TAKKKKKLKN GSSQNGRNER SHMPGTRFSM
     EGISNVIQNG LRHTFGNSGG EKQYLTTVIP YEKKNGPPSV EDLQILTKIL HAMKEDSEKV
     PSLLTDYILK VLCPT