ID   FEZF1_DANRE             Reviewed;         429 AA.
AC   Q25C93;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Fez family zinc finger protein 1;
GN   Name=fezf1; Synonyms=fez;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16540508; DOI=10.1242/dev.02329;
RA   Hirata T., Nakazawa M., Yoshihara S., Miyachi H., Kitamura K.,
RA   Yoshihara Y., Hibi M.;
RT   "Zinc-finger gene Fez in the olfactory sensory neurons regulates
RT   development of the olfactory bulb non-cell-autonomously.";
RL   Development 133:1433-1443(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repressor. Involved in the development of the
CC       forebrain region (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AB207804; BAE87036.1; -; mRNA.
DR   EMBL; BC124439; AAI24440.1; -; mRNA.
DR   RefSeq; NP_001107820.1; NM_001114348.1.
DR   AlphaFoldDB; Q25C93; -.
DR   SMR; Q25C93; -.
DR   STRING; 7955.ENSDARP00000007655; -.
DR   PaxDb; Q25C93; -.
DR   Ensembl; ENSDART00000010325; ENSDARP00000007655; ENSDARG00000010270.
DR   GeneID; 558801; -.
DR   KEGG; dre:558801; -.
DR   CTD; 389549; -.
DR   ZFIN; ZDB-GENE-060929-970; fezf1.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000159477; -.
DR   HOGENOM; CLU_021813_2_1_1; -.
DR   InParanoid; Q25C93; -.
DR   OMA; SQIQHYM; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q25C93; -.
DR   TreeFam; TF316780; -.
DR   PRO; PR:Q25C93; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 25.
DR   Bgee; ENSDARG00000010270; Expressed in camera-type eye and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..429
FT                   /note="Fez family zinc finger protein 1"
FT                   /id="PRO_0000295116"
FT   ZN_FING         247..269
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         275..297
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         303..325
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         331..353
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         359..381
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         387..410
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          409..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           29..44
FT                   /note="Engrailed homology 1 repressor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   429 AA;  47395 MW;  F5814DEC4BE4198A CRC64;
     MDSALYHSAG IFGAPSASTG GSMIASSKPL AFSIERIMAR TPEPKSIPFP NLFQAPVGKA
     EPKQSPAPLH CMIPLMPLAC EPPHKLHING LDHPDTFAYN ANELLSIGLN YKNEQQDAAP
     AIGQYKLFRP RVVNQSSFHA MGAAVCYLNC GEGACPPHAG LVNLHPMASY LLNTPLHARQ
     KSLFSSEKSK QGAVADRCPP GVSFKELSHS HLHHYMKESA HILSEKLFKN SAAKVNSGSP
     QTKPKVFTCE VCGKVFNAHY NLTRHMPVHT GARPFVCKVC GKGFRQASTL CRHKIIHTQE
     KPHKCNQCGK AFNRSSTLNT HTRIHAGYKP FICEFCGKGF HQKGNYKNHK LTHSGEKQFK
     CNICNKAFHQ VYNLTFHMHT HNDKKPFTCP TCGKGFCRNF DLKKHIRKLH DISPGPHSPP
     TPTGNTEGQ