FEZF1_MOUSE
ID FEZF1_MOUSE Reviewed; 475 AA.
AC Q0VDQ9; Q9CXM3;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Fez family zinc finger protein 1;
GN Name=Fezf1; Synonyms=Fez;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=10781957; DOI=10.1016/s0925-4773(00)00264-1;
RA Matsuo-Takasaki M., Lim J.H., Beanan M.J., Sato S.M., Sargent T.D.;
RT "Cloning and expression of a novel zinc finger gene, Fez, transcribed in
RT the forebrain of Xenopus and mouse embryos.";
RL Mech. Dev. 93:201-204(2000).
RN [4]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=16540508; DOI=10.1242/dev.02329;
RA Hirata T., Nakazawa M., Yoshihara S., Miyachi H., Kitamura K.,
RA Yoshihara Y., Hibi M.;
RT "Zinc-finger gene Fez in the olfactory sensory neurons regulates
RT development of the olfactory bulb non-cell-autonomously.";
RL Development 133:1433-1443(2006).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16971467; DOI=10.1242/dev.02585;
RA Hirata T., Nakazawa M., Muraoka O., Nakayama R., Suda Y., Hibi M.;
RT "Zinc-finger genes Fez and Fez-like function in the establishment of
RT diencephalon subdivisions.";
RL Development 133:3993-4004(2006).
CC -!- FUNCTION: Transcription repressor. Involved in the axonal projection
CC and proper termination of olfactory sensory neurons (OSN). Plays a role
CC in rostro-caudal patterning of the diencephalon and in prethalamic
CC formation. Expression is required in OSN to cell-autonomously regulate
CC OSN axon projections. Regulates non-cell-autonomously the layer
CC formation of the olfactory bulb development and the interneurons. May
CC be required for correct rostral migration of the interneuron
CC progenitors. {ECO:0000269|PubMed:16540508,
CC ECO:0000269|PubMed:16971467}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: At 8.0 dpc expressed in prospective forebrain
CC region. At 12.5 dpc, detected in the olfactory epithelium, septum, roof
CC of the telencephalon, amygdala, prethalamus and hypothalamus.
CC Expression was barely detected in the vomeronasal organs at 12.5 dpc.
CC At 15.5 dpc, detected weakly in the olfactory epithelium, amygdala and
CC hypothalamusat 15.5 dpc. Expression was not detected in the olfactory
CC bulb or in the ganglionic eminences, where the interneuron progenitors
CC of the olfactory bulb are generated. {ECO:0000269|PubMed:10781957,
CC ECO:0000269|PubMed:16540508}.
CC -!- DISRUPTION PHENOTYPE: Null mutants were born alive but most of them
CC died within one day. The olfactory bulbs were smaller than those of
CC their wild-type at 18.5 dpc and at postnatal day 1. At 14.5 dpc and 18
CC dpc no abnormalities in the morphology of the telencephalon or
CC diencephalon were detected. There seems to be a redundant role for
CC FEZF1 and FEZF2 in diencephalon development.
CC {ECO:0000269|PubMed:16540508, ECO:0000269|PubMed:16971467}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK014242; BAB29221.1; -; mRNA.
DR EMBL; BC119565; AAI19566.1; -; mRNA.
DR EMBL; BC119566; AAI19567.1; -; mRNA.
DR CCDS; CCDS51725.1; -.
DR RefSeq; NP_082738.1; NM_028462.1.
DR RefSeq; XP_006505238.1; XM_006505175.3.
DR AlphaFoldDB; Q0VDQ9; -.
DR SMR; Q0VDQ9; -.
DR STRING; 10090.ENSMUSP00000031709; -.
DR iPTMnet; Q0VDQ9; -.
DR PhosphoSitePlus; Q0VDQ9; -.
DR PaxDb; Q0VDQ9; -.
DR PRIDE; Q0VDQ9; -.
DR Antibodypedia; 31725; 116 antibodies from 19 providers.
DR Ensembl; ENSMUST00000031709; ENSMUSP00000031709; ENSMUSG00000029697.
DR GeneID; 73191; -.
DR KEGG; mmu:73191; -.
DR UCSC; uc009bbd.2; mouse.
DR CTD; 389549; -.
DR MGI; MGI:1920441; Fezf1.
DR VEuPathDB; HostDB:ENSMUSG00000029697; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159477; -.
DR HOGENOM; CLU_021813_2_1_1; -.
DR InParanoid; Q0VDQ9; -.
DR OMA; SQIQHYM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q0VDQ9; -.
DR TreeFam; TF316780; -.
DR BioGRID-ORCS; 73191; 0 hits in 74 CRISPR screens.
DR PRO; PR:Q0VDQ9; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q0VDQ9; protein.
DR Bgee; ENSMUSG00000029697; Expressed in external naris and 28 other tissues.
DR Genevisible; Q0VDQ9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IMP:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0043697; P:cell dedifferentiation; IGI:UniProtKB.
DR GO; GO:0021797; P:forebrain anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0030900; P:forebrain development; IMP:MGI.
DR GO; GO:1904936; P:interneuron migration; IMP:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IGI:MGI.
DR GO; GO:0021772; P:olfactory bulb development; IMP:MGI.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IGI:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0050767; P:regulation of neurogenesis; IGI:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021537; P:telencephalon development; IMP:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..475
FT /note="Fez family zinc finger protein 1"
FT /id="PRO_0000295115"
FT ZN_FING 260..282
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..423
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 425..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 28..43
FT /note="Engrailed homology 1 repressor"
FT COMPBIAS 436..468
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 178
FT /note="I -> M (in Ref. 1; BAB29221)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 475 AA; 52006 MW; A4DC07D1BA3DE2D1 CRC64;
MDSSCLNATT KMLATAPARG NVMSTSKPLA FSIERIMART PEPKALPVPH FLQGAVPKGD
PKHSLHLNSS IPCMIPFVPV AYDTNSKAGV NGSEPRKASL EVPAPPAVAP SAPAFSCSDL
LNCALSLKGD LARDALPLQQ YKLVRPRVVN HSSFHAMGAL CYLNRGDGPC HPAASVNIHP
VASYFLSSPL HPQPKTYLAE RNKLVVPAVE KLPSGVAFKD LSQAQLQHYM KESAQLLSEK
IAFKTSDFSR GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG KGFHQKGNYK
NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF TCPTCGKGFC RNFDLKKHVR
KLHDSSLGLT RTPTGEPSSD PPPQLQQPPP APLPPLQPTL PPPGPLPSGL HQGHQ
