ID   FEZF1_XENLA             Reviewed;         466 AA.
AC   Q9IAJ2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Fez family zinc finger protein 1;
GN   Name=fezf1; Synonyms=fez;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Forebrain;
RX   PubMed=10781957; DOI=10.1016/s0925-4773(00)00264-1;
RA   Matsuo-Takasaki M., Lim J.H., Beanan M.J., Sato S.M., Sargent T.D.;
RT   "Cloning and expression of a novel zinc finger gene, Fez, transcribed in
RT   the forebrain of Xenopus and mouse embryos.";
RL   Mech. Dev. 93:201-204(2000).
CC   -!- FUNCTION: Transcription repressor. Involved in the development of the
CC       forebrain region. {ECO:0000269|PubMed:10781957}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during mid/late-gastrulation at the
CC       rostro-medial regions of the anterior neural plate. Expression becomes
CC       more pronounced as neurulation progresses and remains localized within
CC       the prospective telencephalic region. By stage 46, expressed in the
CC       olfactory bulbs, nervus terminalis, ventral hypothalamic nucleus, and
CC       ventricular zone. {ECO:0000269|PubMed:10781957}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AF195021; AAF26844.1; -; mRNA.
DR   RefSeq; NP_001082002.1; NM_001088533.1.
DR   AlphaFoldDB; Q9IAJ2; -.
DR   SMR; Q9IAJ2; -.
DR   GeneID; 398172; -.
DR   KEGG; xla:398172; -.
DR   CTD; 398172; -.
DR   Xenbase; XB-GENE-985994; fezf1.S.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 398172; Expressed in neurula embryo and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..466
FT                   /note="Fez family zinc finger protein 1"
FT                   /id="PRO_0000295117"
FT   ZN_FING         261..283
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         289..311
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         317..339
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         345..367
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         373..395
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         401..424
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          446..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           34..49
FT                   /note="Engrailed homology 1 repressor"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        449..466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   466 AA;  52010 MW;  3198461F2E3ED865 CRC64;
     MDSSLQHSTT KILSTQESRE ALSNRLTMIS GAKPLAFSIE RIMSRTPEPK CLPVASLLQS
     SAPKGDQKPG LHINSSSIPR MIPFVPVAYE HCAKIGISGA ELRKSHVDSS PPFSCSDLLN
     CALTLKGDFP REALPLQQYK LVRPRVVNHS SFHAMGAAFC YFNRGDSEWH PPASINIHPM
     ASYFLGSPLH QAPKCYVAAE RNKLLAPSVE KFPSGVTFKD LSQAQFQHYM KEGPRSLSDK
     ITFKTSAKFS SASPSSKPKV FTCEVCGKVF NAHYNLTRHM PVHTGARPFV CKICGKGFRQ
     ASTLCRHKII HTQEKPHKCN QCGKAFNRSS TLNTHTRIHA GYKPFVCEFC GKGFHQKGNY
     KNHKLTHSGE KQFKCNICNK AFHQIYNLTF HMHTHNDKKP FTCPTCGKGF CRNFDLKKHV
     RKLHDNSGSS AGTRGLGATG HQELHLPNRE QSHTIIQSPQ LQKSVY