ID   FEZF1_XENTR             Reviewed;         462 AA.
AC   Q0P4W9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Fez family zinc finger protein 1;
GN   Name=fezf1; Synonyms=fez;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repressor. Involved in the development of the
CC       forebrain region (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC121869; AAI21870.1; -; mRNA.
DR   RefSeq; NP_001072463.1; NM_001078995.1.
DR   AlphaFoldDB; Q0P4W9; -.
DR   SMR; Q0P4W9; -.
DR   STRING; 8364.ENSXETP00000049215; -.
DR   PaxDb; Q0P4W9; -.
DR   DNASU; 779918; -.
DR   Ensembl; ENSXETT00000049215; ENSXETP00000049215; ENSXETG00000022748.
DR   GeneID; 779918; -.
DR   KEGG; xtr:779918; -.
DR   CTD; 389549; -.
DR   Xenbase; XB-GENE-985988; fezf1.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_021813_2_1_1; -.
DR   InParanoid; Q0P4W9; -.
DR   OMA; SQIQHYM; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q0P4W9; -.
DR   TreeFam; TF316780; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022748; Expressed in neurula embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..462
FT                   /note="Fez family zinc finger protein 1"
FT                   /id="PRO_0000295118"
FT   ZN_FING         260..282
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         288..310
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         316..338
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         344..366
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         372..394
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         400..423
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          441..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           34..49
FT                   /note="Engrailed homology 1 repressor"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        447..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51493 MW;  BFC6AA92BDACA9BD CRC64;
     MDSSLQHKTT KIFPSQASRD SLSNRVTMIS GAKPLAFSIE RIMSRTPEPK CLPVPSLLQG
     SVPKGDQKQA LHINSSSIPC MIPFVPVAYD HCPKIGISGA ELRKSHLDSS PPFSCNDLLN
     CALTLKGDFP REALPLQQYK LVRPRVVNHS SFHAMGAAFC YFNRGDSQCH PPASINIHPV
     ASYFLGSPLH QAPKSYLAER NKLVLPSVEK FSSGVTFKDL SQAQFQHYMK EGAHSLSDKI
     TFKTSAKFSS ASPSNKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KICGKGFRQA
     STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG KGFHQKGNYK
     NHKLTHSGEK QFKCNICNKA FHQIYNLTFH MHTHNDKKPF TCPTCGKGFC RNFDLKKHVR
     KLHDSNTAAP HAIGGTGQEE LLLPNREPSP TIQSPQLQKS GY