FEZF2_DANRE
ID FEZF2_DANRE Reviewed; 430 AA.
AC Q804Q5; Q5U371; Q90ZY2; Q9DGC4;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Fez family zinc finger protein 2;
DE AltName: Full=Forebrain embryonic zinc finger-like protein 2;
DE AltName: Full=Foreheadin protein;
DE AltName: Full=Zinc finger protein Fez-like;
GN Name=fezf2; Synonyms=fezl;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11025224; DOI=10.1016/s0925-4773(00)00418-4;
RA Hashimoto H., Yabe T., Hirata T., Shimizu T., Bae Y.-K., Yamanaka Y.,
RA Hirano T., Hibi M.;
RT "Expression of the zinc finger gene fez-like in zebrafish forebrain.";
RL Mech. Dev. 97:191-195(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND
RP KNOCKDOWN.
RX PubMed=11180958; DOI=10.1006/dbio.2000.0139;
RA Yang Z., Liu N., Lin S.;
RT "A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2
RT and dlx6 expression.";
RL Dev. Biol. 231:138-148(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP CHARACTERIZATION OF MUTANT TOF.
RX PubMed=12469125; DOI=10.1038/nn979;
RA Levkowitz G., Zeller J., Sirotkin H.I., French D., Schilbach S.,
RA Hashimoto H., Hibi M., Talbot W.S., Rosenthal A.;
RT "Zinc finger protein too few controls the development of monoaminergic
RT neurons.";
RL Nat. Neurosci. 6:28-33(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription repressor. Component of the regulatory cascade
CC that controls the development of dopaminergic (DA) and serotonergic
CC (5HT) neurons. {ECO:0000269|PubMed:12469125}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11180958}.
CC -!- TISSUE SPECIFICITY: No expression seen in DA or 5HT neurons.
CC {ECO:0000269|PubMed:12469125}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the most anterior part of the
CC prospective neural plate along the rostral-caudal axis. At the tail bud
CC stage, expressed in the prospective forebrain region. From 15-somite to
CC 24 hours post-fertilization (hpf), expression is mostly confined to the
CC telencephalon and the anterior-ventral region of diencephalon
CC Expression is restricted to ectoderm at 80% epiboly stage. From 15-
CC somite to 24 hpf, expression is mostly confined to the telencephalon
CC and the anterior-ventral region of diencephalon.
CC {ECO:0000269|PubMed:11025224, ECO:0000269|PubMed:11180958}.
CC -!- MISCELLANEOUS: In one-eyed pinhead (oep) and cyclops (cyc) mutants,
CC expression in the ventral forebrain was eliminated. Overexpression
CC induced ectopic dlx2 and dlx6 expression. The tof mutant has a reduced
CC number of tyrosine hydroxylase-positive and dopamine beta-hydroxylase-
CC negative DA neurons.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK53550.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL91001.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB041824; BAB16837.1; -; mRNA.
DR EMBL; AF281076; AAK53550.1; ALT_INIT; mRNA.
DR EMBL; AY078361; AAL91001.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL672211; CAD44468.1; -; Genomic_DNA.
DR EMBL; BC085677; AAH85677.1; -; mRNA.
DR AlphaFoldDB; Q804Q5; -.
DR SMR; Q804Q5; -.
DR STRING; 7955.ENSDARP00000094772; -.
DR PaxDb; Q804Q5; -.
DR PRIDE; Q804Q5; -.
DR Ensembl; ENSDART00000184979; ENSDARP00000156395; ENSDARG00000070677.
DR ZFIN; ZDB-GENE-001103-3; fezf2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160100; -.
DR InParanoid; Q804Q5; -.
DR PhylomeDB; Q804Q5; -.
DR PRO; PR:Q804Q5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 11.
DR Bgee; ENSDARG00000070677; Expressed in hypothalamus and 21 other tissues.
DR ExpressionAtlas; Q804Q5; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0021954; P:central nervous system neuron development; IMP:ZFIN.
DR GO; GO:0071679; P:commissural neuron axon guidance; IMP:ZFIN.
DR GO; GO:0021536; P:diencephalon development; IMP:ZFIN.
DR GO; GO:0030900; P:forebrain development; IMP:ZFIN.
DR GO; GO:0021879; P:forebrain neuron differentiation; IMP:ZFIN.
DR GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
DR GO; GO:0021767; P:mammillary body development; IMP:ZFIN.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:ZFIN.
DR GO; GO:0007399; P:nervous system development; IMP:ZFIN.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IMP:ZFIN.
DR GO; GO:0008593; P:regulation of Notch signaling pathway; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..430
FT /note="Fez family zinc finger protein 2"
FT /id="PRO_0000295122"
FT ZN_FING 249..271
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 277..299
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..412
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOTIF 27..42
FT /note="Engrailed homology 1 repressor"
FT MUTAGEN 279
FT /note="C->S: In tof(m808); develops hindbrain 5HT and
FT noradrenergic neurons, but does not develop hypothalamic DA
FT and 5HT neurons."
FT CONFLICT 1
FT /note="M -> V (in Ref. 2; AAK53550)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="S -> P (in Ref. 5; AAH85677)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="R -> K (in Ref. 2; AAK53550)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="Y -> C (in Ref. 2; AAK53550)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="S -> N (in Ref. 2; AAK53550 and 3; AAL91001)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 430 AA; 47541 MW; BF144ECE87F38F0E CRC64;
MASSLPLETV MSCPRLDDRS GATAAPKSLA FSIDRIMSKT SEPKAAAAEE RSEGKKTVGL
CSPIPCMIPI QPFSYDLQAK ALMNYSEFWK VNFRGALCTS AAMCKTNCGV CSKADAGIKH
SVLPGTRVIK PQVIHQALAM PANGSLCYFN YLDSAYQSEL LSGHLFSSAI ANSQAQAISA
HQKLLLLENA KLACVSPEKF PTPQYPHKEH LPGQLDQIVR ESHNLTEKNG VKAHSKTNNC
SSDGKPKNFT CEVCGKVFNA HYNLTRHMPV HTGARPFVCK VCGKGFRQAS TLCRHKIIHT
QEKPHKCNQC GKAFNRSSTL NTHIRIHAGY KPFVCEFCGK GFHQKGNYKN HKLTHSGEKQ
YKCSICSKAF HQIYNLTFHM HTHNDKKPFT CGTCGKGFCR NFDLKKHIRK LHDNANCLSG
GNDSSRGHQN
