ID   FEZF2_XENLA             Reviewed;         434 AA.
AC   Q2TAR3;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Fez family zinc finger protein 2;
GN   Name=fezf2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repressor. Component of the regulatory cascade
CC       that controls the development of dopaminergic (DA) and serotonergic
CC       (5HT) neurons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC110761; AAI10762.1; -; mRNA.
DR   RefSeq; NP_001089933.1; NM_001096464.1.
DR   AlphaFoldDB; Q2TAR3; -.
DR   SMR; Q2TAR3; -.
DR   DNASU; 735002; -.
DR   GeneID; 735002; -.
DR   KEGG; xla:735002; -.
DR   CTD; 735002; -.
DR   Xenbase; XB-GENE-1006438; fezf2.L.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 735002; Expressed in neurula embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..434
FT                   /note="Fez family zinc finger protein 2"
FT                   /id="PRO_0000295123"
FT   ZN_FING         253..275
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         281..303
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         309..331
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         337..359
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         365..387
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         393..416
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   MOTIF           27..42
FT                   /note="Engrailed homology 1 repressor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   434 AA;  48012 MW;  98A1F7AB20A7A7F2 CRC64;
     MSAPLETVMS PCQRLDARTG AAAPPKSLAF SIERIMAKTS EPRAGVFEAN QGLESGAKKT
     LNVCPPVPCM IPIQSLAYDV SPKALLNYSE LWRSSIRGSL CGPSALCKSN CGICCKNDFN
     LSQSLAPSGR VIKPQVINQT LGMPSSGSFY YFNYLESSFH PPDLLNGQLL SSSLINAQSQ
     ATLSAHHKLF LLDNSKLSAL AADKFPNPQF PHKERLPGQL DQVMKENSAL TDRTGKIHTK
     LSANSGEGKP KIFTCEVCGK VFNAHYNLTR HMPVHTGARP FVCKVCGKGF RQASTLCRHK
     IIHTQEKPHK CNQCGKAFNR SSTLNTHIRI HAGYKPFVCE FCGKGFHQKG NYKNHKLTHS
     GEKQYKCSIC NKAFHQVYNL TFHMHTHNDK KPFTCATCGK GFCRNFDLKK HVRKLHDNVS
     SSCSHKEISR TGQS