ID   FEZF2_XENTR             Reviewed;         435 AA.
AC   Q28G88;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Fez family zinc finger protein 2;
GN   Name=fezf2; ORFNames=TGas068o03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repressor. Component of the regulatory cascade
CC       that controls the development of dopaminergic (DA) and serotonergic
CC       (5HT) neurons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; CR761501; CAJ83894.1; -; mRNA.
DR   EMBL; BC136188; AAI36189.1; -; mRNA.
DR   RefSeq; NP_001016305.1; NM_001016305.3.
DR   RefSeq; XP_012816536.1; XM_012961082.2.
DR   AlphaFoldDB; Q28G88; -.
DR   SMR; Q28G88; -.
DR   STRING; 8364.ENSXETP00000048138; -.
DR   PaxDb; Q28G88; -.
DR   DNASU; 549059; -.
DR   GeneID; 549059; -.
DR   KEGG; xtr:549059; -.
DR   CTD; 55079; -.
DR   Xenbase; XB-GENE-1006432; fezf2.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q28G88; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022248; Expressed in neurula embryo and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..435
FT                   /note="Fez family zinc finger protein 2"
FT                   /id="PRO_0000295124"
FT   ZN_FING         254..276
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         282..304
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         310..332
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         338..360
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         366..388
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         394..417
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   MOTIF           27..42
FT                   /note="Engrailed homology 1 repressor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   435 AA;  48055 MW;  CE03F904BD013A6B CRC64;
     MAAPLETVMT PCQRFDGRNG ASATPKSLAF SIERIMAKTS EPKAAAFQPS QGLDPGAKKM
     LNLCSPLPCM IPIQSLAYDV HSKALLNYSE LWKSSLRGSV CSPSGLCKSN CGICCKNDLN
     MGHTVLPGSR VIKPQVINQT VGLPTNGSLY YFNYLDSSFH PPEILSGQLL SSSLINAQSQ
     ATLSAQQKLF LLENAKLSGL APEKFPNPQY PHKERLPGQL DQVMKENSAL SADRSGKIHS
     KLGANSAEGK PKIFTCEVCG KVFNAHYNLT RHMPVHTGAR PFVCKVCGKG FRQASTLCRH
     KIIHTQEKPH KCNQCGKAFN RSSTLNTHIR IHAGYKPFVC EFCGKGFHQK GNYKNHKLTH
     SGEKQYKCTI CNKAFHQIYN LTFHMHTHND KKPFTCGTCG KGFCRNFDLK KHVRKLHDNV
     SSSCSLKEIS RTGQS