ID   FFKA_ANTEL              Reviewed;           4 AA.
AC   P58705;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   11-DEC-2019, entry version 34.
DE   RecName: Full=Antho-KAamide;
OS   Anthopleura elegantissima (Green aggregating anemone) (Actinia
OS   elegantissima).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anthopleura.
OX   NCBI_TaxID=6110;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ALA-4.
RX   PubMed=1681803; DOI=10.1016/0006-291x(91)91700-m;
RA   Nothacker H.-P., Rinehart K.L. Jr., Grimmelikhuijzen C.J.P.;
RT   "Isolation of L-3-phenyllactyl-Phe-Lys-Ala-NH2 (Antho-KAamide), a novel
RT   neuropeptide from sea anemones.";
RL   Biochem. Biophys. Res. Commun. 179:1205-1211(1991).
RN   [2]
RP   FUNCTION.
RX   PubMed=8397415; DOI=10.1098/rspb.1993.0100;
RA   McFarlane I.D., Hudman D., Nothacker H.-P., Grimmelikhuijzen C.J.P.;
RT   "The expansion behaviour of sea anemones may be coordinated by two
RT   inhibitory neuropeptides, Antho-KAamide and Antho-RIamide.";
RL   Proc. R. Soc. B 253:183-188(1993).
CC   -!- FUNCTION: Inhibits spontaneous contractions in several muscle groups.
CC       May be involved in the expansion phase of feeding behavior in sea
CC       anemones. {ECO:0000269|PubMed:8397415}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neuron specific.
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DR   PIR; JQ1273; JQ1273.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..4
FT                   /note="Antho-KAamide"
FT                   /id="PRO_0000043714"
FT   MOD_RES         1
FT                   /note="3-phenyllactic acid"
FT                   /evidence="ECO:0000269|PubMed:1681803"
FT   MOD_RES         4
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:1681803"
SQ   SEQUENCE   4 AA;  512 MW;  6DD339C9A0000000 CRC64;
     FFKA